4-(2,5-Dimethoxy-phenyl)-2-hydroxy-4-oxo-butyric acid methyl ester | 23349-27-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,5-Dimethoxy-phenyl)-2-hydroxy-4-oxo-butyric acid methyl ester
• CAS: 23349-27-1
• 化学式: C₁₃H₁₆O₆
• 分子量: 268.266
• InChiKey: JVOWDTGWCRACGL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-(2,5-Dimethoxy-phenyl)-2-hydroxy-4-oxo-butyric acid methyl ester 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates

  摘要：

  Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2'-hydroxy)phenylbutanoates derived from L-malic acid. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2015.07.006