4-(4-N-甲基-苯氧基)吡啶-2-甲酰胺 | 943314-89-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-(4-N-甲基-苯氧基)吡啶-2-甲酰胺
• 英文名称: 4-(4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide
• 英文别名: N-Methyl-4-(4-(methylamino)phenoxy)picolinamide；N-methyl-4-[4-(methylamino)phenoxy]pyridine-2-carboxamide
• CAS: 943314-89-4
• 化学式: C₁₄H₁₅N₃O₂
• 分子量: 257.292
• InChiKey: WGYCXLGTZGOZTR-UHFFFAOYSA-N

物化性质

• 沸点：
  467.2±40.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
  申请人：BENTZIEN Joerg Martin

  公开号：US20140045813A1

  公开（公告）日：2014-02-13

  The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.

  本发明涵盖了以下式（I）的化合物： 其中A、Cy、X1和Y团在此处定义，适用于治疗与BTK相关的疾病，包括制备过程、含有化合物的药物制剂以及它们的使用方法。
• NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Lang Hengyuan

  公开号：US20070155764A1

  公开（公告）日：2007-07-05

  The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.

  本发明涉及化合物和方法，用作蛋白激酶的抑制剂，包括B-Raf以及几种受体酪氨酸激酶和细胞质酪氨酸激酶。本发明涉及新的取代嘧啶氧基脲化合物II、III和IV的配方及其作为药物治疗疾病的应用。还提供了在人类或动物主体中调节蛋白激酶活性的方法，用于治疗癌症等疾病。
• [EN] NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES<br/>[FR] UREES PYRIMIDINYLOXY SUBSTITUEES UTILES COMME INHIBITEURS DES PROTEINES KINASES
  申请人：KALYPSYS INC

  公开号：WO2007076473A2

  公开（公告）日：2007-07-05

  [EN] The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.
  [FR] Composés et procédés utiles pour l'inhibition des protéines kinases, y compris les kinases B-Raf et plusieurs tyrosines kinases de type récepteur tyrosine et cytoplasmique. On décrit des composés d'urées pyrimidinyloxy substituées de formules II, III et IV et des compositions, et leur application comme produits pharmaceutiques pour le traitement de maladies. On décrit également des procédés de modulation d'activité de protéine kinase chez un sujet humain ou animal, pour le traitement de maladies comme le cancer.
• [EN] COMPOSITIONS FOR TREATING LIVER CANCER COMPRISING A VASCULAR DISRUPTING AGENT<br/>[FR] COMPOSITIONS DE TRAITEMENT DU CANCER DU FOIE COMPRENANT UN AGENT DE DESTRUCTION VASCULAIRE
  申请人：CHONG KUN DANG PHARMACEUTICAL CORP

  公开号：WO2018021827A1

  公开（公告）日：2018-02-01

  The present disclosure provides compositions for treatment or adjuvant treatment of liver cancer, comprising (S)-N-(4-(3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl)thiazol-2-yl)-2-amino-3-methylbutanamide or a pharmaceutically acceptable salt thereof. The compositions of the present disclosure exhibit an excellent effect of treating liver cancer.