4-(4-三氟甲基苯甲酰基)哌啶盐酸盐 | 25519-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-(4-三氟甲基苯甲酰基)哌啶盐酸盐
• 英文名称: piperidin-4-yl(4-(trifluoromethyl)phenyl)methanone hydrochloride
• 英文别名: Piperidin-4-yl-(4-trifluoromethylphenyl)methanone hydrochloride；piperidin-4-yl-[4-(trifluoromethyl)phenyl]methanone;hydrochloride
• CAS: 25519-83-9
• 化学式: C₁₃H₁₄F₃NO*ClH
• 分子量: 293.716
• InChiKey: HCCJUYRHQMAMMX-UHFFFAOYSA-N

物化性质

• 熔点：
  196-198°C
• 溶解度：
  溶于甲醇、水

计算性质

• 辛醇/水分配系数(LogP)：
  3.31
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.1
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H315,H319,H335

文献信息

• [EN] NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA<br/>[FR] NOUVEAUX COMPOSÉS APPROPRIÉS POUR LE TRAITEMENT DE LA DYSLIPIDÉMIE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2022130352A1

  公开（公告）日：2022-06-23

  Present invention relates to compounds of general formula (I), their tautomeric forms, stereoisomers, pharmaceutically acceptable salts and pharmaceutical composition containing them. Invention also relates to process for the preparation of compounds of general formula (I) and intermediates thereof. Compounds of present invention can be useful in treating diseases such as hyperlipidemia and other disorders related to hyperlipidemia. Compounds of present invention also have a beneficial effect on lowering cholesterol.

  本发明涉及一般式（I）的化合物，它们的互变异构体，立体异构体，药学上可接受的盐和含有它们的药物组合物。本发明还涉及制备一般式（I）化合物和中间体的过程。本发明的化合物可用于治疗高脂血症等与高脂血症相关的疾病。本发明的化合物还具有降低胆固醇的益处。
• OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3768684A1

  公开（公告）日：2021-01-27
• [EN] OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS<br/>[FR] INHIBITEURS D'OXAZINE MO NO AC YLG LYCE RO L LIPASE (MAGL)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2019180185A1

  公开（公告）日：2019-09-26

  The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.