(5Z)-5-butylidene-1',3-dimethyl-2-thioxospiro[imidazolidine-4,3'-indol]-2'(1'H)-one | 1172630-90-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5Z)-5-butylidene-1',3-dimethyl-2-thioxospiro[imidazolidine-4,3'-indol]-2'(1'H)-one
• 英文别名: (4Z)-4-butylidene-1,1'-dimethyl-2-sulfanylidenespiro[imidazolidine-5,3'-indole]-2'-one
• CAS: 1172630-90-8
• 化学式: C₁₆H₁₉N₃OS
• 分子量: 301.412
• InChiKey: VNDDIRVUZDFRKX-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3a-butyl-1,5-dimethyl-9b-hydroxy-2-thioxo-1,2,3,3a,5,9b-hexahydroimidazo[4,5-c]quinolin-4-one 在 溶剂黄146 作用下， 反应 3.0h， 以49%的产率得到(5Z)-5-butylidene-1',3-dimethyl-2-thioxospiro[imidazolidine-4,3'-indol]-2'(1'H)-one
  参考文献：
  名称：

  Reaction of 1-substituted 3-aminoquinoline-2,4-diones with isothiocyanates. An easy pathway to generate novel 2-thioxo-1′H-spiro[imidazoline-5,3′-indole]-2,2′-diones

  摘要：

  3-Butyl-3-amino-1H,3H-quinoline-2.4-diones react with isothiocyanates to give novel 3a-butyl-9b-hydroxy-2-thioxo-1,2,3,3a,5,9b-hexahydro-imidazo[4,5-c]quinolin-2-ones in high yields. These compounds rearrange in boiling acetic acid or concd hydrochloric acid to give (E)- and/or (Z)-4-butylidene-2-thioxo-1'H-spiro[imidazoline-5,3'-indole]-2,2'-diones. All compounds were characterized by their (1)H, (13)C, IR and MS spectra, and some of them also by (15)N NMR. The structure of one compound was investigated by single-crystal X-ray diffraction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.009

文献信息

• Reaction of 1-substituted 3-aminoquinoline-2,4-diones with isothiocyanates. An easy pathway to generate novel 2-thioxo-1′H-spiro[imidazoline-5,3′-indole]-2,2′-diones
  作者：Antonín Klásek、Vladimír Mrkvička、Antonín Lyčka、Ivan Mikšík、Aleš Růžička

  DOI：10.1016/j.tet.2009.04.009

  日期：2009.6

  3-Butyl-3-amino-1H,3H-quinoline-2.4-diones react with isothiocyanates to give novel 3a-butyl-9b-hydroxy-2-thioxo-1,2,3,3a,5,9b-hexahydro-imidazo[4,5-c]quinolin-2-ones in high yields. These compounds rearrange in boiling acetic acid or concd hydrochloric acid to give (E)- and/or (Z)-4-butylidene-2-thioxo-1'H-spiro[imidazoline-5,3'-indole]-2,2'-diones. All compounds were characterized by their (1)H, (13)C, IR and MS spectra, and some of them also by (15)N NMR. The structure of one compound was investigated by single-crystal X-ray diffraction. (C) 2009 Elsevier Ltd. All rights reserved.