(4aR,5R,7R,8S,8aS)-7-(azidomethyl)-8-hydroxy-5-methoxy-5,7,8,8a-tetrahydro-4aH-pyrano[3,4-b][1,4]dioxin-2-one | 1169754-33-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4aR,5R,7R,8S,8aS)-7-(azidomethyl)-8-hydroxy-5-methoxy-5,7,8,8a-tetrahydro-4aH-pyrano[3,4-b][1,4]dioxin-2-one
• CAS: 1169754-33-9
• 化学式: C₉H₁₃N₃O₆
• 分子量: 259.219
• InChiKey: PJLXZTWFOFTCJI-DFPOFIQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  88.6
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 水 作用下， 以20%的产率得到(4aR,5R,7R,8S,8aS)-7-(azidomethyl)-8-hydroxy-5-methoxy-5,7,8,8a-tetrahydro-4aH-pyrano[3,4-b][1,4]dioxin-2-one
  参考文献：
  名称：

  A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

  摘要：

  Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli O157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-alpha-1,4-Gal ligand for verotoxin in eight steps and in similar to 10% overall yield. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.02.021

文献信息

• A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin
  作者：Darren Gibson、Steven W. Homans、Robert A. Field

  DOI：10.1016/j.tetasy.2009.02.021

  日期：2009.5

  Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli O157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-alpha-1,4-Gal ligand for verotoxin in eight steps and in similar to 10% overall yield. (C) 2009 Elsevier Ltd. All rights reserved.