1-(2-(2,4-dimethoxyphenyl)-2-oxoethyl)-N-(thiazol-2-yl)-1H-indazole-5-sulfonamide | 1104806-70-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-(2,4-dimethoxyphenyl)-2-oxoethyl)-N-(thiazol-2-yl)-1H-indazole-5-sulfonamide
• 英文别名: 1-[2-(2,4-dimethoxyphenyl)-2-oxoethyl]-N-(1,3-thiazol-2-yl)indazole-5-sulfonamide
• CAS: 1104806-70-3
• 化学式: C₂₀H₁₈N₄O₅S₂
• 分子量: 458.519
• InChiKey: YTGDOWUXXHMINT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  149
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SODIUM CHANNEL INHIBITORS
  申请人：Icagen, Inc.

  公开号：EP2173743A2

  公开（公告）日：2010-04-14
• US8124610B2
  申请人：——

  公开号：US8124610B2

  公开（公告）日：2012-02-28
• [EN] SODIUM CHANNEL INHIBITORS<br/>[FR] INHIBITEURS DES CANAUX SODIQUES
  申请人：ICAGEN INC

  公开号：WO2009012242A2

  公开（公告）日：2009-01-22

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compos i-tiona comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel. Formula (II)