1-[[6-[1-(Cyclopropylmethyl)piperidin-4-yl]oxypyridin-3-yl]methyl]-3-[5-methyl-2-(trifluoromethyl)furan-3-yl]urea | 1222557-12-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[[6-[1-(Cyclopropylmethyl)piperidin-4-yl]oxypyridin-3-yl]methyl]-3-[5-methyl-2-(trifluoromethyl)furan-3-yl]urea
• CAS: 1222557-12-1
• 化学式: C₂₂H₂₇F₃N₄O₃
• 分子量: 452.477
• InChiKey: CMXBCVOXXYWCPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Azine Derivatives and Methods of Use Thereof
  申请人：Palani Anandan

  公开号：US20110207734A1

  公开（公告）日：2011-08-25

  The present invention relates to Azine Derivatives, pharmaceutical compositions comprising the Azine Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.