1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[(1R,3R)-3-(3-isopropyl[1,2,4]triazolo[4,3a]pyridin-6-yloxy)-indan-1-yl]urea | 1351997-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[(1R,3R)-3-(3-isopropyl[1,2,4]triazolo[4,3a]pyridin-6-yloxy)-indan-1-yl]urea
• 英文别名: 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[(1R,4R)-4-(3-isopropyl[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)indan-1-yl]urea；1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[(1R,3R)-3-[(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-2,3-dihydro-1H-inden-1-yl]urea
• CAS: 1351997-03-9
• 化学式: C₃₃H₃₇N₇O₂
• 分子量: 563.702
• InChiKey: RYHJTUJGWRWJCZ-KAYWLYCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  98.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• UREA DERIVATIVES AND THEIR THERAPEUTIC USE IN THE TREATMENT OF, INTER ALIA, DISEASES OF THE RESPIRATORY TRACT
  申请人：Woo Chi-Kit

  公开号：US20130143914A1

  公开（公告）日：2013-06-06

  Compounds of formula (I) are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory wherein R 1 is a radical of formula (IA) or (IB) or (IC): 10 Y is -0- or —S(0) p - wherein p is 0, 1 or 2; A is an optionally substituted cycloalkylene radical having 5, 6 or 7 ring atoms fused to a phenyl ring; and R 2 , R3b and R4b are as defined in the claims.

  式(I)的化合物是p38 MAPK抑制剂，在治疗呼吸系统疾病等炎症疾病中作为抗炎药物有用，其中R1是式(IA)或(IB)或(IC)的基团：Y是-0-或-S(0)p-，其中p为0、1或2；A是一个有5、6或7个环原子与苯环融合的可选择取代的环烷基基团；而R2、R3b和R4b如权利要求中所定义。
• Urea derivatives and their therapeutic use in the treatment of, inter alia, diseases of the respiratory tract
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：EP2580212B1

  公开（公告）日：2015-01-28
• US8916708B2
  申请人：——

  公开号：US8916708B2

  公开（公告）日：2014-12-23