3-(tert-butyldimethylsilyloxy)-3-(4-(tert-butyldimethylsilyloxy) phenyl)-N-methoxy-N-methylpropanamide | 1449521-91-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(tert-butyldimethylsilyloxy)-3-(4-(tert-butyldimethylsilyloxy) phenyl)-N-methoxy-N-methylpropanamide
• CAS: 1449521-91-8
• 化学式: C₂₃H₄₃NO₄Si₂
• 分子量: 453.77
• InChiKey: DHGAAMNOWNVZJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.54
• 重原子数：
  30.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  48.0
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-(tert-butyldimethylsilyloxy)-3-(4-(tert-butyldimethylsilyloxy) phenyl)-N-methoxy-N-methylpropanamide 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 异丙醇 、 甲苯 为溶剂， 反应 6.83h， 生成 3-(methoxy(methyl)amino)-1-(4-methoxyphenyl)-3-oxopropyl 2-(2-(tert-butyldimethylsilyloxy)-2-(4-(tert-butyldimethylsilyloxy)phenyl)ethyl)-4,6-dihydroxybenzoate
  参考文献：
  名称：

  Synthetic studies towards tragoponol: preparation of a highly functionalized resorcylate

  摘要：

  Studies on the synthesis of racemic tragoponol are described. The western resorcylate unit of tragoponol was efficiently constructed from appropriate diketo-dioxinone and secondary alcohol intermediates using a ketene generation-trapping and aromatization sequence. Further functionalization provided an advanced diketo-dioxinone intermediate which upon desilylation resulted in the formation of a dihydroisocoumarin. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.044
• 作为产物：
  描述：

  Ethyl 3-hydroxy-3-(4-hydroxyphenyl)propanoate 在 咪唑 、 异丙基氯化镁 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 18.42h， 生成 3-(tert-butyldimethylsilyloxy)-3-(4-(tert-butyldimethylsilyloxy) phenyl)-N-methoxy-N-methylpropanamide
  参考文献：
  名称：

  Synthetic studies towards tragoponol: preparation of a highly functionalized resorcylate

  摘要：

  Studies on the synthesis of racemic tragoponol are described. The western resorcylate unit of tragoponol was efficiently constructed from appropriate diketo-dioxinone and secondary alcohol intermediates using a ketene generation-trapping and aromatization sequence. Further functionalization provided an advanced diketo-dioxinone intermediate which upon desilylation resulted in the formation of a dihydroisocoumarin. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.044