N(Boc2)Hse(TBDPS)-OMe | 534602-90-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N(Boc2)Hse(TBDPS)-OMe
• 英文别名: methyl (2S)-2-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]-4-[tert-butyl(diphenyl)silyl]oxybutanoate
• CAS: 534602-90-9
• 化学式: C₃₁H₄₅NO₇Si
• 分子量: 571.786
• InChiKey: KUZPSDWBLCIYSJ-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.67
• 重原子数：
  40
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N(Boc2)Hse(TBDPS)-OMe 在 正丁基锂 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 [(S)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-oxo-pentyl]-phosphonic acid dimethyl ester
  参考文献：
  名称：

  Synthesis of non-Natural C2-Homo-ceramide and its apoptotic activity against HL-60 cells

  摘要：

  Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from L-aspartic acid via L-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01026-0
• 作为产物：
  描述：

  N,N-di-tert-butoxycarbonyl L-aspartic acid dimethyl ester 在 咪唑 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 N(Boc2)Hse(TBDPS)-OMe
  参考文献：
  名称：

  Structure–Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer

  摘要：

  DOI：

  10.1021/acs.jnatprod.0c00921

文献信息

• Structure–Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer
  作者：Luping Yan、Carmen A. Banuelos、Nasrin R. Mawji、Brian O. Patrick、Marianne D. Sadar、Raymond J. Andersen

  DOI：10.1021/acs.jnatprod.0c00921

  日期：2021.3.26
• Synthesis of non-Natural C2-Homo-ceramide and its apoptotic activity against HL-60 cells
  作者：Keiji Shikata、Hayato Niiro、Hideki Azuma、Taro Tachibana、Kenji Ogino

  DOI：10.1016/s0960-894x(02)01026-0

  日期：2003.2

  Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from L-aspartic acid via L-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide. (C) 2003 Elsevier Science Ltd. All rights reserved.