[4-(4-Cyanobenzoyl)phenyl]α-D-glucopyranoside | 345341-70-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-(4-Cyanobenzoyl)phenyl]α-D-glucopyranoside
• 英文别名: 4-[4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzoyl]benzonitrile
• CAS: 345341-70-0
• 化学式: C₂₀H₁₉NO₇
• 分子量: 385.373
• InChiKey: ABDMMLFMCSPZAI-PKOFMYQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Benzophenone alpha-d-glycopyranosides, preparation and therapeutic use
  申请人：——

  公开号：US20030139349A1

  公开（公告）日：2003-07-24

  The invention concerns (i) [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides of formula (I) wherein: the group &agr;-D-glycopyranosyl R represents a &agr;-D-glycopyranosyl, &agr;-D-galactopyranosyl. &agr;-D-mannopyranosyl, &agr;-D-arabinopyranosyl, &agr;-D-lyxopyranosyl, or &agr;-D-ribopyranosyl group: (ii) their esters resulting from the esterification of at least a OH function of each pyranosyl group with a C 2 -C 4 alkanoic or a cycloalkanoic acid, as novel industrial products. Said novel [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides are useful in therapy for fighting against atheromatous plaque.

  该发明涉及公式(I)中的(4-(4-氰基苄基)苯基)α-D-葡萄糖苷，其中：α-D-葡萄糖苷R代表α-D-葡萄糖苷，α-D-半乳糖苷，α-D-阿拉伯糖苷，α-D-利索糖苷或α-D-核糖苷基团：(ii)它们是通过将每个吡喃糖基的至少一个OH功能与C2-C4烷酸或环烷酸酯化而得到的酯，作为新的工业产品。这些新型(4-(4-氰基苄基)苯基)α-D-葡萄糖苷在治疗动脉粥样硬化斑块方面具有用途。
• BENZOPHENONE ALPHA-D-GLYCOPYRANOSIDES, PREPARATION ET UTILISATION EN THERAPEUTIQUE
  申请人：FOURNIER INDUSTRIE ET SANTE

  公开号：EP1240177A2

  公开（公告）日：2002-09-18
• [EN] BENZOPHENONE ALPHA-D-GLYCOPYRANOSIDES, PREPARATION AND THERAPEUTIC USE<br/>[FR] BENZOPHENONE alpha -D-GLYCOPYRANOSIDES, PREPARATION ET UTILISATION EN THERAPEUTIQUE
  申请人：——

  公开号：WO2001047941A3

  公开（公告）日：2001-12-27

  [EN] The invention concerns (i) [4-(4-cyanobenzyl)phenyl] alpha -D-glycopyranosides of formula (I) wherein: the group alpha -D-glycopyranosyl R represents a alpha -D-glycopyranosyl, alpha -D-galactopyranosyl, alpha -D-mannopyranosyl, alpha -D-arabinopyranosyl, alpha -D-lyxopyranosyl, or alpha -D-ribopyranosyl group; (ii) their esters resulting from the esterification of at least a OH function of each pyranosyl group with a C2-C4 alkanoic or a cycloalkanoic acid, as novel industrial products. Said novel [4-(4-cyanobenzyl)phenyl] alpha - D-glycopyranosides are useful in therapy for fighting against atheromatous plaque.
  [FR] La présente invention concerne en tant que produits industriels nouveaux: (i) les [4-(4-cyanobenzoyl)phényl] alpha -D-glycopyranosides de formule (I): dans laquelle le groupe alpha -D-glycopyranosyle R représente un groupe alpha -D-glycopyranosyle, alpha -D-galactopyranosyle, alpha -D-mannopyranosyle, alpha -D-arabinopyranosyle, alpha -D-lyxopyranosyle, ou alpha -D-ribopyranosyle; et, (ii) leurs esters résultant de l'estérification d'au moins d'une fonction OH de chaque groupe glycopyranosyle par un acide alcanoïque ou cycloalcanoïque en C2-C4. Ces nouveaux [4-(4-cyanobenzoyl)phényl] alpha -D-glycopyranosides sont utiles en thérapeutique vis-à-vis de la plaque d'athérome.