(E)-8-phenyloct-2-enoic acid | 370064-80-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-8-phenyloct-2-enoic acid
• CAS: 370064-80-5
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: LAXFLNGOTKUVHH-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-8-phenyloct-2-enoic acid 在 正丁基锂 、 草酰氯 、 三氟甲磺酸二丁硼 、 二甲基氯化铝 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.83h， 生成 3-(S)-(5-phenylpentyl)-aziridine-2-(R)-carboxylic acid benzyl ester
  参考文献：
  名称：

  Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds

  摘要：

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00641-x
• 作为产物：
  描述：

  (E)-8-phenyloct-2-enoic acid methyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 48.0h， 以96%的产率得到(E)-8-phenyloct-2-enoic acid
  参考文献：
  名称：

  Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds

  摘要：

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00641-x

文献信息

• MACROCYCLIZATION OF COMPOUNDS FROM SOLID SUPPORT USING THIOESTERASES
  申请人：Sherman David H.

  公开号：US20090111152A1

  公开（公告）日：2009-04-30

  A method of preparing macrocycles using solid support chemistry and thioesterases is disclosed. Also disclosed are novel macrocycles.

  本发明公开了一种使用固相支持化学和硫酯酶制备大环化合物的方法。同时还公开了新型大环化合物。
• AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150005348A1

  公开（公告）日：2015-01-01

  An amide compound represented by formula (I) has an excellent pest control effect. (In the formula, Y represents a 3-7 membered saturated heterocyclic ring which contains, as ring-forming components(s), one or more atoms or groups that are selected from the group consisting of an oxygen atom and —S(O) t —, the saturated heterocyclic ring may have one to three atoms or groups selected from group D and t represents 0 or the like; x represents a C 1 -C 8 chain hydrocarbon group having one group that is selected from group A; W represents —CR 8 — or the like; r represents 1 or the like; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 may be the same or different and each represents a hydrogen atom or the like; and n represents 1 or the like.)

  式(I)所代表的酰胺化合物具有出色的杀虫效果。（在该式中，Y代表一个含有3-7个饱和杂环环的结构，该结构中包含一个或多个从氧原子和-S(O)t-组成的原子或基团，饱和杂环环可能有一个到三个从D组成的原子或基团，t代表0或类似物；x代表一个C1-C8链烃基，其中有一个来自A组的基团；W代表-CR8-或类似物；r代表1或类似物；R1、R2、R3、R4、R5、R6、R7和R8可以相同也可以不同，每个代表一个氢原子或类似物；n代表1或类似物。）
• US8114640B2
  申请人：——

  公开号：US8114640B2

  公开（公告）日：2012-02-14
• [EN] MACROCYCLIZATION OF COMPOUNDS FROM SOLID SUPPORT USING THIOESTERASES<br/>[FR] MACROCYCLISATION DE COMPOSÉS À PARTIR D'UN SUPPORT SOLIDE À L'AIDE DE THIOESTÉRASES
  申请人：UNIV MICHIGAN OFFICE OF TECHNO

  公开号：WO2009059002A2

  公开（公告）日：2009-05-07

  A method of preparing macrocycles using solid support chemistry and thioesterases is disclosed. Also disclosed are novel macrocycles.
• Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds
  作者：Stephen Hanessian、Nicolas Moitessier、Louis-David Cantin

  DOI：10.1016/s0040-4020(01)00641-x

  日期：2001.8

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.