succinimido-p-benzyl-dihydrocinnamate | 277332-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: succinimido-p-benzyl-dihydrocinnamate
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 3-(4-benzylphenyl)propanoate；(2,5-dioxopyrrolidin-1-yl) 3-(4-benzylphenyl)propanoate
• CAS: 277332-37-3
• 化学式: C₂₀H₁₉NO₄
• 分子量: 337.375
• InChiKey: PXRFTHGVEMPISE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  succinimido-p-benzyl-dihydrocinnamate 、 Phosphoric acid 4-amino-butyl ester (2R,3S,4S,5R)-3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethyl ester 在 TEAB buffer 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 BnDC-Glc-6-P 、 BnDC-Glc-6-P
  参考文献：
  名称：

  Preparation and use of a photoactivatable glucose-6-phosphate analogue

  摘要：

  A benzophenone-containing derivative of glucose-6-phosphate, 6-[(3-([2,3-H-3(2)]-p-benzoyl dihydrocinnamidoylpropyl-1-oxy)phosphoryl]-D-glucopyranose ([H-3]BZDC-Glc-6-P) was synthesized and employed to photoaffinity label proteins on intact rat liver microsomes. The use of a non-photoactivatable, UV-transparent desoxy analogue of BZDC, named p-benzyldihydrocinnamoyl (BnDC), is introduced as a general method to achieve competition when hydrophilic ligands are modified with hydrophobic photophores. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00043-3
• 作为产物：
  描述：

  succinimido-p-benzoylcinnamate 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以69%的产率得到succinimido-p-benzyl-dihydrocinnamate
  参考文献：
  名称：

  Preparation and use of a photoactivatable glucose-6-phosphate analogue

  摘要：

  A benzophenone-containing derivative of glucose-6-phosphate, 6-[(3-([2,3-H-3(2)]-p-benzoyl dihydrocinnamidoylpropyl-1-oxy)phosphoryl]-D-glucopyranose ([H-3]BZDC-Glc-6-P) was synthesized and employed to photoaffinity label proteins on intact rat liver microsomes. The use of a non-photoactivatable, UV-transparent desoxy analogue of BZDC, named p-benzyldihydrocinnamoyl (BnDC), is introduced as a general method to achieve competition when hydrophilic ligands are modified with hydrophobic photophores. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00043-3

文献信息

• Preparation and use of a photoactivatable glucose-6-phosphate analogue
  作者：Jirong Peng、Pei Yan Chen、Richard B Marchase、Glenn D Prestwich

  DOI：10.1016/s0960-894x(00)00043-3

  日期：2000.3

  A benzophenone-containing derivative of glucose-6-phosphate, 6-[(3-([2,3-H-3(2)]-p-benzoyl dihydrocinnamidoylpropyl-1-oxy)phosphoryl]-D-glucopyranose ([H-3]BZDC-Glc-6-P) was synthesized and employed to photoaffinity label proteins on intact rat liver microsomes. The use of a non-photoactivatable, UV-transparent desoxy analogue of BZDC, named p-benzyldihydrocinnamoyl (BnDC), is introduced as a general method to achieve competition when hydrophilic ligands are modified with hydrophobic photophores. (C) 2000 Elsevier Science Ltd. All rights reserved.