1,2-Benzoxazol-3-ylmethanesulfonamide;2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one | 944389-00-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-Benzoxazol-3-ylmethanesulfonamide;2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
• CAS: 944389-00-8
• 化学式: C21H26ClN3O4S
• 分子量: 452.0
• InChiKey: ISAMYVPKXXKYOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Chemosensory receptor ligand-based therapies
  申请人：Anji Pharma (US) LLC

  公开号：US10610500B2

  公开（公告）日：2020-04-07

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含化感受体配体（如苦味受体配体）的组合物来治疗与化感受体相关的病症（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了化学感觉受体配体组合物，包括苦味受体配体组合物，及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES
  申请人：Elcelyx Therapeutics, Inc

  公开号：EP2560660A1

  公开（公告）日：2013-02-27
• BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Elcelyx Therapeutics, Inc.

  公开号：EP2800561A1

  公开（公告）日：2014-11-12
• Chemosensory Receptor Ligand-Based Therapies
  申请人：BARON Alain

  公开号：US20110065660A1

  公开（公告）日：2011-03-17

  Provided herein are methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions comprising chemosensory receptor ligands. Also provided herein are chemosensory receptor ligand compositions and the preparation thereof for the methods of the present invention.