5-(1,3-dioxolan-2-yl)-2-oxo-pentanoic Acid | 255893-64-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 5-(1,3-dioxolan-2-yl)-2-oxo-pentanoic Acid
• 英文别名: 5-(1,3-dioxolan-2-yl)-2-oxopentanoic acid
• CAS: 255893-64-2
• 化学式: C₈H₁₂O₅
• 分子量: 188.18
• InChiKey: XSVZRFJEIGUDES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(1,3-dioxolan-2-yl)-2-oxo-pentanoic Acid 以86-97.5的产率得到(S)-2-氨基-5-(1,3-二氧戊环-2-基)戊酸
  参考文献：
  名称：

  Biomolecular Engineering. 2001, 17, 167-182

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(1,3-Dioxolan-2-yl)-2-oxo-pentanoic acid, ethyl ester 生成 5-(1,3-dioxolan-2-yl)-2-oxo-pentanoic Acid
  参考文献：
  名称：

  Biomolecular Engineering. 2001, 17, 167-182

  摘要：

  DOI：

文献信息

• Substituted alkylketo compounds and process
  申请人：——

  公开号：US20020049342A1

  公开（公告）日：2002-04-25

  Substituted alkylketo compounds of the formula 1 can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.

  化学式1的取代烷基酮化合物可以通过立体选择性的酶法转化为相应的氨基酸。得到的氨基酸化合物可以作为药用活性化合物的起始原料。本发明涉及取代烷基酮化合物及其制备方法。
• Pichia pastoris formate dehydrogenase and uses therefor
  申请人：Goldberg L. Steven

  公开号：US20060100422A1

  公开（公告）日：2006-05-11

  This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

  本发明涉及一种重组毕赤酵母甲酸脱氢酶（FDH）酶，该酶催化甲酸氧化为二氧化碳，同时还还原烟酰胺腺嘌呤二核苷酸（NAD+）为其还原形式（NADH）。本发明还涉及编码P. pastoris FDH多肽的分离核酸，以及其片段和变体，以及包含这些核酸的载体和宿主细胞。此外，本发明还涉及分离的重组P. pastoris FDH多肽，以及其片段和变体，以及特异性结合P. pastoris FDH多肽、片段或变体的抗体。本发明还涉及获得分离的P. pastoris FDH核酸、多肽和抗体的方法，以及在工业或制药应用中使用P. pastoris FDH的方法。
• Stereoselective reductive amination of ketones
  申请人：Bristol-Myers Squibb Company

  公开号：US06468781B1

  公开（公告）日：2002-10-22

  Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

  本发明涉及一种对某些酮羧酸衍生物进行立体选择性酶催化转化以形成相应的烷基氨基酸化合物的方法。本发明还涉及一种工程酵母宿主细胞，其含有能够表达苯丙氨酸脱氢酶的重组核酸，以及一种工程宿主细胞，其含有能够表达苯丙氨酸脱氢酶酶和能够表达甲酸脱氢酶酶的重组核酸。
• STEREOSELECTIVE REDUCTIVE AMINATION OF KETONES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1097236A1

  公开（公告）日：2001-05-09
• EP1097236A4
  申请人：——

  公开号：EP1097236A4

  公开（公告）日：2006-10-04