N,N'-Bis-naphthalen-1-ylmethyl-butane-1,4-diamine | 287968-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N'-Bis-naphthalen-1-ylmethyl-butane-1,4-diamine
• 英文别名: 1,4-Butanediamine, N,N'-bis(1-naphthalenylmethyl)-；N,N'-bis(naphthalen-1-ylmethyl)butane-1,4-diamine
• CAS: 287968-59-6
• 化学式: C₂₆H₂₈N₂
• 分子量: 368.522
• InChiKey: HUTFIRDOUMNKCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N'-Bis-[1-naphthalen-1-yl-meth-(E)-ylidene]-butane-1,4-diamine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 20.0h， 以8.42 g的产率得到N,N'-Bis-naphthalen-1-ylmethyl-butane-1,4-diamine
  参考文献：
  名称：

  Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens

  摘要：

  A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00156-7

文献信息

• Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens
  作者：Mark R Burns、Solveig LaTurner、Josh Ziemer、Maralee McVean、Bruce Devens、C.Lance Carlson、Gerard F Graminski、Scott M Vanderwerf、Reitha S Weeks、Jay Carreon

  DOI：10.1016/s0960-894x(02)00156-7

  日期：2002.5

  A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents and the distance between amino groups the most potent analogues were analyzed biologically and were shown to induce apoptosis. These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.