6-甲氧基-2-吡啶硫醇1-氧化物 | 496879-25-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-甲氧基-2-吡啶硫醇1-氧化物
• 英文名称: 6-methoxy-2-mercaptopyridine-N-oxide
• CAS: 496879-25-5
• 化学式: C₆H₇NO₂S
• 分子量: 157.193
• InChiKey: ZYCHWLKFJGZXHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  36.17
• 氢给体数：
  1.0
• 氢受体数：
  3.0

文献信息

• Antivesicant compounds and methods of making and using thereof
  申请人：——

  公开号：US20030055090A1

  公开（公告）日：2003-03-20

  As disclosed herein, the present invention provides a compound having the structural formula 1 wherein R 1 , R 2 , R 3 , and R 4 are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or acyloxy group, or a pharmaceutically acceptable salt or prodrug thereof. Also disclosed are compounds, compositions, methods and kits for treating, preventing, or inhibiting injuries induced by a vesicant agent, such as bis-2-chloroethylsulfide (HD). Additionally, protectants and decontaminants are disclosed.

  根据本文所披露的，本发明提供了具有结构式1的化合物，其中R1、R2、R3和R4分别独立地为H，或者是甲基、卤素、三氟甲基、硝基、烷氧基或酰氧基基团，或其药用可接受的盐或前药。还披露了用于治疗、预防或抑制由泡状剂引发的损伤的化合物、组合物、方法和试剂盒，例如双-2-氯乙基亚砜（HD）。此外，还披露了保护剂和脱污剂。
• ANTIVESICANT COMPOUNDS AND METHODS OF MAKING AND USING THEREOF
  申请人：U.S. Army Medical Research and Materiel Command

  公开号：EP1435953A1

  公开（公告）日：2004-07-14
• EP1435953A4
  申请人：——

  公开号：EP1435953A4

  公开（公告）日：2005-05-04
• US6664280B2
  申请人：——

  公开号：US6664280B2

  公开（公告）日：2003-12-16
• [EN] ANTIVESICANT COMPOUNDS AND METHODS OF MAKING AND USING THEREOF<br/>[FR] COMPOSES ANTIVESICANTS ET PROCEDES DE FABRICATION ET D'UTILISATION ASSOCIES
  申请人：US ARMY MED RES MAT COMMAND

  公开号：WO2003011292A1

  公开（公告）日：2003-02-13

  As disclosed herein, the present invention provides a compound having the structural formula (I) wherein R?1, R2, R3, and R4¿ are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or acyloxy group, or a pharmaceutically acceptable salt or prodrug thereof. Also disclosed are compounds, compositions, methods and kits for treating, preventing, or inhibiting injuries induced by a vesicant agent, such as bis-2-chloroethylsulfide (HD). Additionally, protectants and decontaminants are disclosed.