5-sec-Butyl-2-acetylthiophene | 855609-39-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-sec-Butyl-2-acetylthiophene
• 英文别名: 1-(5-sec-butyl-[2]thienyl)-ethanone；1-(5-sec-Butyl-[2]thienyl)-aethanon；1-(5-Butan-2-ylthiophen-2-yl)ethanone
• CAS: 855609-39-1
• 化学式: C₁₀H₁₄OS
• 分子量: 182.287
• InChiKey: JGNKYSBYQQUIFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-sec-Butyl-2-acetylthiophene 在 硫酸 、 potassium nitrate 作用下， 反应 0.5h， 以52%的产率得到5-sec-Butyl-4-nitro-2-acetylthiophene
  参考文献：
  名称：

  噻吩系列硝基酮的还原乙酰化

  摘要：

  DOI：

  10.1007/bf00503182
• 作为产物：
  描述：

  乙酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铝 、 Petroleum ether 作用下， 生成 5-sec-Butyl-2-acetylthiophene
  参考文献：
  名称：

  Hydrogen Transfer. IV.¹ Reaction of p-Isobutyltoluene and of p-s-Butyltoluene with Methylcyclohexene

  摘要：

  DOI：

  10.1021/ja01160a038

文献信息

• 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
  申请人：Samumed, LLC

  公开号：US10383861B2

  公开（公告）日：2019-08-20

  6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

  本发明公开了用于治疗各种疾病和病理的 6-氮杂吲唑化合物。更具体地说，本公开涉及 6-氮杂吲唑化合物或其类似物在治疗以 Wnt 通路信号激活为特征的疾病（如癌症、异常细胞增殖、血管生成、纤维化疾病、骨或软骨疾病以及骨关节病）中的用途、癌症、异常细胞增殖、血管生成、纤维化疾病、骨或软骨疾病和骨关节炎）、调节由 Wnt 通路信号介导的细胞事件以及由于 Wnt 通路和/或一种或多种 Wnt 信号元件的突变或失调引起的遗传性疾病和神经状况/失调/疾病。此外，还提供了治疗 Wnt 相关疾病状态的方法。
• 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINE AND THERAPEUTIC USES THEREOF
  申请人：Samumed, LLC

  公开号：US20170224697A1

  公开（公告）日：2017-08-10

  Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
• 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
  申请人：Samumed, LLC

  公开号：US20180221351A1

  公开（公告）日：2018-08-09

  6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.