2-butyl-5-methyloxazole | 1393588-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-butyl-5-methyloxazole
• 英文别名: 2-Butyl-5-methyl-1,3-oxazole；2-butyl-5-methyl-1,3-oxazole
• CAS: 1393588-62-9
• 化学式: C₈H₁₃NO
• 分子量: 139.197
• InChiKey: FFMQIKIGOSZFCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-propargylpentanamide 在 iron(III) chloride 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 生成 2-butyl-5-methyloxazole
  参考文献：
  名称：

  Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI₂ and FeCl₃

  摘要：

  An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI2 and FeCl3 is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.

  DOI：

  10.1021/ol301980g

文献信息

• Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI₂ and FeCl₃
  作者：Gopal Chandru Senadi、Wan-Ping Hu、Jia-Shing Hsiao、Jaya Kishore Vandavasi、Chung-Yu Chen、Jeh-Jeng Wang

  DOI：10.1021/ol301980g

  日期：2012.9.7

  An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI2 and FeCl3 is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.