(R)-2-Amino-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester | 112954-79-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-Amino-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester
• 英文别名: (R)-tert-Butyl2-amino-6-(((benzyloxy)carbonyl)amino)hexanoate；tert-butyl (2R)-2-amino-6-(phenylmethoxycarbonylamino)hexanoate
• CAS: 112954-79-7
• 化学式: C₁₈H₂₈N₂O₄
• 分子量: 336.431
• InChiKey: AKFVZALISNAFRA-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-2-Amino-6-benzyloxycarbonylamino-hexanoic acid tert-butyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 D-Lys-O-tert-Bu
  参考文献：
  名称：

  Regioselective Modification of Lysine's Amino Groups by Proteases.

  摘要：

  研究了六种丝氨酸蛋白酶对赖氨酸氨基的区域选择性。α-胰蛋白酶显示出对α-氨基的偏好，尽管根据反应介质的不同，选择性可变化 10 倍。Subtilisin Carlsberg 和其他细菌蛋白酶对ε-氨基具有高度特异性，与反应介质无关：它们被用作催化剂，在无水叔戊醇中制备合成异肽。

  DOI：

  10.1271/bbb1961.55.3067

文献信息

• PSMA imaging agents
  申请人：Wang Eric

  公开号：US10011632B2

  公开（公告）日：2018-07-03

  Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

  本研究公开了用于靶向前列腺特异性膜抗原（PSMA）的化合物和成像剂。还公开了合成化合物和成像剂的方法，以及 PSMA 的成像方法。所公开的成像剂适用于 PET 和 SPECT 成像。
• PSMA Imaging Agents
  申请人：WANG Eric

  公开号：US20160304555A1

  公开（公告）日：2016-10-20

  Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
• [EN] PSMA IMAGING AGENTS<br/>[FR] AGENTS D'IMAGERIE DU PSMA
  申请人：SIEMENS MEDICAL SOLUTIONS

  公开号：WO2013028664A1

  公开（公告）日：2013-02-28

  Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
• [EN] PSMA TARGETED RADIOHALOGENATED UREAS FOR CANCER RADIOTHERAPY<br/>[FR] URÉES RADIOHALOGÉNÉES CIBLÉES SUR LE PSMA POUR LA RADIOTHÉRAPIE DU CANCER
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2017070482A2

  公开（公告）日：2017-04-27

  PPSMA binding scaffolds with radioiodinated, radiobrominated and radioastatinated labeled prosthetic groups are disclosed. Pharmaceutical compositions and methods of treating PSMA expressing cells or tumors also are disclosed.
• Regioselective Modification of Lysine's Amino Groups by Proteases.
  作者：Hiroshi KITAGUCHI、Mitsunori ONO、Isamu ITOH、Alexander M. KLIBANOV

  DOI：10.1271/bbb1961.55.3067

  日期：——

  The regioselectivity of six serine proteases for the amino groups of lysine was investigated. α-Chymotrypsin showed a preference for the α-amino group, although the selectivity can be varied 10-fold depending on the reaction medium. Subtilisin Carlsberg and other bacterial proteases were highly specific for the ε-amino group, regardless of the reaction medium: they were used as catalysts for the preparative synthesis of isopeptides in anhydrous tert-amyl alcohol.

  研究了六种丝氨酸蛋白酶对赖氨酸氨基的区域选择性。α-胰蛋白酶显示出对α-氨基的偏好，尽管根据反应介质的不同，选择性可变化 10 倍。Subtilisin Carlsberg 和其他细菌蛋白酶对ε-氨基具有高度特异性，与反应介质无关：它们被用作催化剂，在无水叔戊醇中制备合成异肽。