ω-Brom-2-butoxy-acetophenon | 22165-37-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ω-Brom-2-butoxy-acetophenon
• 英文别名: 2-bromo-2'-butoxyacetophenone；2-Bromo-1-(2-butoxyphenyl)ethanone
• CAS: 22165-37-3
• 化学式: C₁₂H₁₅BrO₂
• 分子量: 271.154
• InChiKey: KCHHWUMLJBDINE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CONTRAST AGENTS<br/>[FR] AGENTS DE CONTRASTE
  申请人：BRACCO IMAGING SPA

  公开号：WO2017178301A1

  公开（公告）日：2017-10-19

  The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

  本发明涉及一类新型的功能化多氮杂环，至少含有一个与环状笼的氮原子相连的磷onic或磷inic基团，并且能够螯合顺磁性金属离子，及其与金属离子的螯合复合物，以及它们作为对比剂的使用，特别适用于磁共振成像（MRI）分析。
• [EN] COMPOSITIONS AND METHODS FOR TREATING CANCER<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DU CANCER
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2017213897A1

  公开（公告）日：2017-12-14

  Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.

  本文提供了用于治疗、抑制和/或减轻患有癌症的受试者的组合物和方法。该方法包括提供一种抑制ONECUT2表达或活性的药剂，并向受试者施用治疗有效量的该药剂，以治疗、抑制和/或减轻受试者体内癌症的严重程度。
• [EN] COMPOSITIONS AND METHODS OF REGULATING CANCER RELATED DISORDERS AND DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE RÉGULATION DE TROUBLES ET MALADIES ASSOCIÉS AU CANCER
  申请人：ONCO THERAPIES LLC

  公开号：WO2017070052A1

  公开（公告）日：2017-04-27

  Provided herein are naphthylic derivative compounds, or pharmaceutically acceptable salts thereof, that are useful for inhibiting cancers. Also provided herein are methods of using effective amounts of said compounds, optionally with pharmaceutical carriers, for the treatment of cancers within human subjects.

  本文提供了萘基衍生物化合物或其药用盐，用于抑制癌症。本文还提供了使用有效量的该化合物的方法，可选地与药用载体一起，用于治疗人体内的癌症。
• Method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes which are used in asymmetric reduction reactions
  申请人：Burgos Alain

  公开号：US20070055068A1

  公开（公告）日：2007-03-08

  A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.

  一种用于原位制备从氧杂硼烷硼酸盐复合物中衍生的手性化合物的方法，其中将金属硼氢化物、路易斯碱和无机酸酯混合，然后加入手性活性氨基醇和可选的卤化物。所得化合物是一种复合物，可用作不对称还原反应中的催化剂。通过将待还原物质，特别是原始手性酮或醚肟加入以合成手性醇或手性胺来执行反应。
• Process for producing optically active carbinols
  申请人：SUMIKA FINE CHEMICALS Company, Limited

  公开号：EP0713848A1

  公开（公告）日：1996-05-29

  The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active α-phenyl-substituted-β-amino alcohols of the formula (3) or optically active α-non-substituted-β-amino alcohols of the formula (4). The present invention further relates to a process for producing optically active carbinols, comprising reacting with an unsymmetric ketone, an asymmetric reducing agent obtained from optically active β-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid.

  本发明涉及一种生产光学活性的式(1)卤代甲基苯基甲醇的工艺，包括使用从硼烷和光学活性的式(3)α-苯基取代-β-氨基醇或光学活性的式(4)α-非取代-β-氨基醇中得到的不对称还原剂还原式(2)卤代甲基苯基酮。 本发明还涉及一种生产光学活性烷醇的工艺，包括与不对称酮、从式（5）光学活性β-氨基醇中得到的不对称还原剂、金属硼氢化物和路易斯酸或低级二烷基硫酸反应。