3-(4-methylphenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one | 61963-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-methylphenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one
• 英文别名: 3-(p-tolyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one；3-p-tolyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one；1,3-dihydro-3-(4-methylphenyl)imidazo[4,5-b]pyridin-2-one；3-(4-Methylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one；3-(4-methylphenyl)-1H-imidazo[4,5-b]pyridin-2-one
• CAS: 61963-02-8
• 化学式: C₁₃H₁₁N₃O
• 分子量: 225.25
• InChiKey: GUEYCGUFCZUIPS-UHFFFAOYSA-N

物化性质

• 熔点：
  220-222 °C(Solv: 1-propanol (71-23-8))
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基-2-氯吡啶 、 乙烷,三氯氟- 、 尿素 以47%的产率得到3-(4-methylphenyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-one
  参考文献：
  名称：

  Synthesis of 1-and 3-substituted imidazo[4,5-b]pyridin-2-ones

  摘要：

  1- and 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210 degrees C. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p'-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, respectively.

  DOI：

  10.1134/s1070428006060145

文献信息

• Multivalent VLA-4 antagonists comprising polymer moieties
  申请人：Elan Pharmaceuticals Inc.

  公开号：EP2258399A2

  公开（公告）日：2010-12-08

  Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

  公开了结合 VLA-4 的共轭物。其中某些共轭物还能抑制白细胞粘附，特别是由 VLA-4 介导的白细胞粘附。此类共轭物可用于治疗哺乳动物患者（如人类）的炎症性疾病，如哮喘、阿尔茨海默病、动脉粥样硬化、艾滋病痴呆症、糖尿病、炎症性肠病、类风湿性关节炎、组织移植、肿瘤转移和心肌缺血。共轭物还可用于治疗脑部炎症性疾病，如多发性硬化症。
• US4144341A
  申请人：——

  公开号：US4144341A

  公开（公告）日：1979-03-13
• [EN] METHODS AND COMPOSITIONS FOR TREATING LIQUID TUMORS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER DES TUMEURS LIQUIDES
  申请人：ELAN PHARM INC

  公开号：WO2009075806A1

  公开（公告）日：2009-06-18

  The application relates to a method of using compositions having anti-alpha- 4 integrin and/or anti- alpha-9 integrin activity to inhibit liquid tumor growth, malignancies thereof and/or development of metastases thereof that involve expression of an alpha-4 integrin and/or alpha-9 integrin. Pharmaceutical compositions and combination therapies (for example, with chemotherapies) for the inhibition of liquid tumor growth, malignancies thereof and/or development of metastases thereof are also provided.