羟基红地那非 | 147676-56-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 羟基红地那非
• 英文名称: Hydroxyacetildenafil
• 英文别名: 5-[2-ethoxy-5-[2-[4-(2-hydroxyethyl)piperazin-1-yl]acetyl]phenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
• CAS: 147676-56-0
• 化学式: C₂₅H₃₄N₆O₄
• 分子量: 482.6
• InChiKey: RZVZQPAGIOECPK-UHFFFAOYSA-N

物化性质

• 熔点：
  129-132°C
• 密度：
  1.33±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS
  申请人：Strategic Science & Technologies, LLC

  公开号：US20160263120A1

  公开（公告）日：2016-09-15

  The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
• US9498482B2
  申请人：——

  公开号：US9498482B2

  公开（公告）日：2016-11-22
• US9833456B2
  申请人：——

  公开号：US9833456B2

  公开（公告）日：2017-12-05