(4-Iodo-phenyl)-phosphoramidic acid mono-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester | 56209-81-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Iodo-phenyl)-phosphoramidic acid mono-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
• 英文别名: [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-N-(4-iodophenyl)phosphonamidic acid
• CAS: 56209-81-5
• 化学式: C₁₅H₁₇IN₃O₈P
• 分子量: 525.194
• InChiKey: JPKLBCJFGXVMBL-FMKGYKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  158
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS
  申请人：Katholieke Universiteit Leuven, K.U. Leuven R&D

  公开号：EP2424874A1

  公开（公告）日：2012-03-07
• NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS
  申请人：Herdewijn Piet

  公开号：US20120108533A1

  公开（公告）日：2012-05-03

  This invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R 1 ; R 3 and R 2 . are s defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.
• [EN] NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS<br/>[FR] NOUVEAUX NUCLÉOSIDES MODIFIÉS PAR PHOSPHATE UTILES COMME SUBSTRATS POUR DES POLYMÉRASES ET COMME AGENTS ANTIVIRAUX
  申请人：UNIV LEUVEN KATH

  公开号：WO2010125200A1

  公开（公告）日：2010-11-04

  This invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R1; R3 and R2. are s defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.