4-(N-己基氨基)苯甲酸 | 55791-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(N-己基氨基)苯甲酸
• 英文名称: N-hexyl-4-aminobenzoic acid
• 英文别名: 4-(hexylamino)benzoic acid；4-hexylamino-benzoic acid；4-Hexylamino-benzoesaeure；4-(n-hexylamino)benzoic acid；4-Hexylaminobenzoesaeure
• CAS: 55791-76-9
• 化学式: C₁₃H₁₉NO₂
• mdl: MFCD00102120
• 分子量: 221.299
• InChiKey: LXOKKPODGWECLI-UHFFFAOYSA-N

物化性质

• 沸点：
  362.36°C (rough estimate)
• 密度：
  1.0451 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(N-己基氨基)苯甲酸 、 4-硝基苯甲酰氯 在 N,N-二甲基苯胺 作用下， 以 丙酮 为溶剂， 以90%的产率得到N-hexyl-4-(4-nitrobenzamido)benzoic acid
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligo(p-benzamide) Foldamers

  摘要：

  A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as well as N-hexyl protected monomers were investigated. Heterosequences of both monomers were synthesized. Such nanoscale objects are important building blocks for supramolecular chemistry.

  DOI：

  10.1021/ol0603357
• 作为产物：
  描述：

  N-(4-methoxycarbonylphenyl)-n-hexylamine 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以0.9 g的产率得到4-(N-己基氨基)苯甲酸
  参考文献：
  名称：

  罗替戈汀前药衍生物、其药物组合物及其用途

  摘要：

  本发明属于医药技术领域，具体涉及罗替戈汀前药衍生物、其药物组合物及其在制备用于预防或治疗与多巴胺受体有关疾病中的用途。罗替戈汀前药衍生物，包括具有式（Ⅰ）所示结构的化合物：#imgabs0#本发明的罗替戈汀前药衍生物在体内经酯酶代谢产生罗替戈汀，使罗替戈汀的血药浓度波动小，有效血药浓度维持时间长，可以降低给药次数，提高患者顺应性。

  公开号：

  CN117105906A

文献信息

• Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogs of cetaben
  作者：J. Donald Albright、Vern G. DeVries、Elwood E. Largis、Thomas G. Miner、Marvin F. Reich、Sheldon A. Schaffer、Robert G. Shepherd、Janis Upeslacis

  DOI：10.1021/jm00364a009

  日期：1983.10

  the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro for activity in inhibiting the principle cholesterol-esterifying enzyme of the arterial wall, fatty acyl-CoA:cholesterol acyltransferase (ACAT). Based on a combination of these two activities, cataben sodium (150) was selected for development

  描述了一系列（芳烷基氨基）-和（烷基氨基）苯甲酸的合成，以及相应的酯和钠盐。在大鼠体内评估了该化合物的血清甾醇和甘油三酸酯降低活性，并且在体外评估了该化合物在抑制动脉壁的主要胆固醇酯化酶，脂肪酰基-CoA：胆固醇酰基转移酶（ACAT）中的活性。基于这两种活性的结合，选择了卡本苯甲酸钠（150）作为降血脂药和潜在的抗动脉粥样硬化药物开发。
• Norvaline Derivative and Method for Preparation Thereof
  申请人：Harada Naoyuki

  公开号：US20080076769A1

  公开（公告）日：2008-03-27

  Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2). [wherein X is —CH 2 —, —O—, —S— or single bond; Ar is optionally substituted aryl or lower cycloalkyl; n is 0 to 2; R 1 and R 2 are (i) each is hydrogen or lower alkyl; (ii) R 1 and R 2 are combined to form lower alkylene; or (iii) R 1 is hydrogen or lower alkyl and R 2 is combined with R 4 or R 6 to form lower alkylene; R 3 and R 4 are (i) each is hydrogen or lower alkyl; (ii) R 3 and R 4 are combined to form lower alkylene; or (iii) R 3 is hydrogen or lower alkyl and R 4 is combined with R 2 or R 6 to form lower alkylene; R is or —OR 7 ; R 5 and R 6 are (i) each is optionally substituted lower alkyl, or hydrogen; (ii) R 5 and R 6 are combined to form aliphatic 5- to 6-membered heterocyclic group; or (iii) R 5 is optionally substituted lower alkyl or hydrogen and R 6 is combined with R 2 or R 4 to form lower alkylene; R 7 is lower alkyl.

  Norvaline衍生物的化学式[I]或其药学上可接受的盐，制备方法，含有该化合物的药物组合物，以及用于抑制甘氨酸转运体2型（GlyT2）的转运活性的用途。[其中X为-CH2-，-O-，-S-或单键；Ar为可选取代芳基或较低的环烷基；n为0至2；R1和R2为（i）氢或较低的烷基；（ii）R1和R2结合形成较低的烷基；或（iii）R1为氢或较低的烷基，R2与R4或R6结合形成较低的烷基；R3和R4为（i）氢或较低的烷基；（ii）R3和R4结合形成较低的烷基；或（iii）R3为氢或较低的烷基，R4与R2或R6结合形成较低的烷基；R为-OH或-OR7；R5和R6为（i）可选取代的较低烷基或氢；（ii）R5和R6结合形成脂肪族5-至6-成员杂环基；或（iii）R5为可选取代的较低烷基或氢，R6与R2或R4结合形成较低的烷基；R7为较低烷基。
• Propylene polymers and their production
  申请人：SHELL OIL COMPANY

  公开号：EP0320150A2

  公开（公告）日：1989-06-14

  An ultra high molecular melt flow rate propylene polymer in which the molecular weight distribution Q is not inversely proportional to the melt flow rate is produced, without post-reactor treatment, by contacting propylene and hydrogen, in the gas phase in the presence of a high activity catalyst.

  一种分子量分布 Q 与熔体流动速率不成反比的超高分子熔体流动速率丙烯聚合物，是在一种高活性催化剂存在下，通过气相中丙烯与氢的接触，在不进行反应后处理的情况下生产出来的。
• An immunoaffinity substrate
  申请人：Hewlett-Packard Company

  公开号：EP0303406A2

  公开（公告）日：1989-02-15

  Novel affinity columns are provided by linking glycoproteins through the carbohydrate residue to sup­ports. Oxidative cleavage of a sugar residue provides an aldehyde, which is condensed with an active amino functionality on the surface (and subsequent reduction if necessary) to provide for affinity columns where binding sites are substantially unaffected by the chemistry and are oriented to optimize binding to the complementary binding member.

  通过碳水化合物残基将糖蛋白与支撑物连接，可提供新型亲和柱。糖残基的氧化裂解可产生醛，醛与表面的活性氨基官能团缩合（如有必要，还可随后还原），从而形成亲和柱，亲和柱的结合位点基本上不受化学作用的影响，其方向可优化与互补结合成员的结合。
• Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination
  作者：Gitte Van Baelen、Bert U.W. Maes

  DOI：10.1016/j.tet.2008.03.028

  日期：2008.6

  Microwave-assisted hydrolysis of benzonitriles and methyl benzoates has been studied using a toluene/concd aq KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed. (c) 2008 Elsevier Ltd. All rights reserved.