3-O-methyl-D-gluconic acid | 1195491-41-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-methyl-D-gluconic acid
• 英文别名: 3-O-Methyl-D-gluconsaeure；(2R,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-methoxyhexanoic acid
• CAS: 1195491-41-8
• 化学式: C₇H₁₄O₇
• 分子量: 210.184
• InChiKey: HNNWBLAAROIANI-KAZBKCHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-O-甲基-D-葡萄糖 在 platinum on activated charcoal 氢氧化钾 作用下， 以 水 为溶剂， 25.0 ℃ 、101.32 kPa 条件下， 反应 3.0h， 生成 3-O-methyl-D-gluconic acid
  参考文献：
  名称：

  碱性溶液中还原糖的催化脱氢

  摘要：

  摘要碱性介质中的醛类在铂或铑的催化作用下被高选择性地转化为醛糖酸，并伴随着氢气的逸出。已经针对25种不同的单糖和二糖研究了脱氢反应，该反应通常可用于还原糖。研究了几个反应变量的影响，得出了一个吸附模型，在该模型中，带负电荷的O-1和H-1与催化剂表面的紧密接触均被视为推动氢化物从C-转移的动力。将1的糖加入催化剂中。

  DOI：

  10.1016/s0008-6215(00)86025-5

文献信息

• Schmidt; Simon, Journal fur praktische Chemie (Leipzig 1954), 1939, vol. <2> 152, p. 190,197, 198
  作者：Schmidt、Simon

  DOI：——

  日期：——
• THE REACTIVITY OF THE METHYLATED SUGARS. VI. THE ACTION OF DILUTE ALKALI ON 3-METHYLGLUCOSE¹
  作者：Donald J. Loder、W. Lee Lewis

  DOI：10.1021/ja01342a027

  日期：1932.3
• PROCESS FOR THE PRODUCTION AND SEPARATION OF 5- HYDROXYMETHYLFURFURAL WITH QUATERNARY AMMONIUM SALTS
  申请人：Novamont S.p.A.

  公开号：EP3820855A1

  公开（公告）日：2021-05-19
• PROCESS FOR THE PRODUCTION AND SEPARATION OF 5-HYDROXYMETHYLFURFURAL WITH QUATERNARY AMMONIUM SALTS
  申请人：Novamont S.P.A.

  公开号：US20210292290A1

  公开（公告）日：2021-09-23

  The present invention relates to a process for the production and separation of 5-hydroxymethylfurfural (HMF) comprising the steps of: (1) dehydrating at least one saccharide selected from the group consisting of monosaccharides having 6 carbon atoms and disaccharides, oligosaccharides and polysaccharides formed from units having 6 carbon atoms or mixtures thereof, in the presence of water and of at least one quaternary ammonium salt, at a temperature between 80-130° C., obtaining a reaction mixture comprising the quaternary ammonium salt, HMF and any unreacted saccharide; and (2) subjecting the said reaction mixture to at least one membrane separation operation selected in the group consisting of nanofiltration, reverse osmosis, electrodialisis and their combinations, obtaining an aqueous permeate comprising HMF and a retentate comprising quaternary ammonium salt, wherein both the dehydration of step (1) and the separation operations of step (2) are carried out in the absence of organic solvents.
• [EN] PROCESS FOR THE PRODUCTION AND SEPARATION OF 5- HYDROXYMETHYLFURFURAL WITH QUATERNARY AMMONIUM SALTS<br/>[FR] PROCÉDÉ DE PRODUCTION ET DE SÉPARATION DE 5-HYDROXYMÉTHYLFURFURAL À L'AIDE DE SELS D'AMMONIUM QUATERNAIRE
  申请人：NOVAMONT SPA

  公开号：WO2020011996A1

  公开（公告）日：2020-01-16

  The present invention relates to a process for the production and separation of 5-hydroxymethylfurfural (HMF) comprising the steps of: (1) dehydrating at least one saccharide selected from the group consisting of monosaccharides having 6 carbon atoms and disaccharides, oligosaccharides and polysaccharides formed from units having 6 carbon atoms or mixtures thereof, in the presence of water and of at least one quaternary ammonium salt, at a temperature between 80-130 ° C, obtaining a reaction mixture comprising the quaternary ammonium salt, HMF and any unreacted saccharide; and (2) subjecting the said reaction mixture to at least one membrane separation operation selected in the group consisting of nanofiltration, reverse osmosis, electrodialisis and their combinations, obtaining an aqueous permeate comprising HMF and a retentate comprising quaternary ammonium salt, wherein both the dehydration of step (1) and the separation operations of step (2) are carried out in the absence of organic solvents.