E-6-phenyl-2-cyclodecen-1-one | 471279-58-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: E-6-phenyl-2-cyclodecen-1-one
• 英文别名: (2E)-6-phenylcyclodec-2-en-1-one
• CAS: 471279-58-0
• 化学式: C₁₆H₂₀O
• 分子量: 228.334
• InChiKey: BKORJQJKVUTVGB-WUXMJOGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Cyclooctanone derivatives and cyclodecanone derivative, and use thereof
  申请人：——

  公开号：US20040082805A1

  公开（公告）日：2004-04-29

  The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -D E- represents a group represented by —CH 2 CH 2 — or —CH═CH—; W represents a group represented by —CH 2 —, —CH 2 CH 2 —, —CH═CH— or —CH═; the partial structure >X Y—represents a group represented by >CH—(CH 2 ) n —, >C═CH—, >CH—CH 2 —CH(OH)—, >CH—CH 2 —C(═O)—, >CH—O— or >CH—O—CO—, provided that when W is —CH═, then X Y— represents C—(CH 2 ) p —; Z represents a divalent aliphatic hydrocarbon group; R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1].

  本发明提供了一种具有细胞因子生产抑制活性的化合物，可用于治疗与细胞因子相关的疾病。该化合物由以下通式(I)表示：[其中，A表示可以被取代的环状基团；部分结构-DE-表示由— —或—CH═CH—表示的基团；W表示由—CH2—、— —、—CH═CH—或—CH═—表示的基团；部分结构>XY-表示由>CH—( )n—、>C═CH—、>CH— —CH(OH)—、>CH— —C(═O)—、>CH—O—或>CH—O—CO—表示的基团，但当W为—CH═时，XY—表示C—( )p—；Z表示二价的脂肪族碳氢基团；R1和R2，可以相同也可以不同，每个表示氢原子或羟基、烷氧基或烷氧基烷基；m是0或1的整数。]
• PYRROLIDINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
  申请人：Eisai Co., Ltd.

  公开号：EP1375479A1

  公开（公告）日：2004-01-02

  The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -D---E- represents a group represented by -CH2CH2- or -CH=CH-; W reprensents a group represented by -CH2-, - CHzCH2-, -CH=CH- or -CH=; the partial structure >X---Y- represents a group represented by >CH-(CH2)n-, >C=CH-, >CH-CH2-CH(OH)-, >CH-CH2-C (=O) -, >CH-O- or >CH-O-CO-, provided that when W is -CH=, then X---Y- represents C-(CH2)p-; Z represents a divalent aliphatic hydrocarbon group; R1 and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1] .

  本发明提供了一种化合物，它具有抑制细胞因子产生的活性，可用于治疗与细胞因子有关的疾病。该化合物由以下通式（I）表示[其中 A 代表可被取代的环状基团；部分结构-D--E-代表由- -或-CH=CH-代表的基团；W 代表由-CH2-、-CHz -、-CH=CH-或-CH=；部分结构 >X---Y- 代表由 >CH-( )n-、>C=CH-、>CH- -CH(OH)-、>CH- -C (=O) -、>CH-O- 或 >CH-O-CO- 所代表的基团，条件是当 W 为 -CH= 时，则 X---Y- 代表 C-( )p-；Z 代表二价脂肪族烃基； R1 和 R2 可以相同或不同，各自代表氢原子或羟基、烷氧基或烷氧烷氧基； m 是 0 或 1 的整数]。
• CYCLOOCTANONE DERIVATIVE AND CYCLODECANONE DERIVATIVE, AND USE THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1375465A9

  公开（公告）日：2004-04-14

  The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -D---E- represents a group represented by -CH2CH2- or -CH=CH-; W reprensents a group represented by -CH2-, - CH2CH2-, -CH=CH- or -CH=; the partial structure >X---Y- represents a group represented by >CH-(CH2)n-, >C=CH-, >CH-CH2-CH(OH)-, >CH-CH2-C (=O) -, >CH-O- or >CH-O-CO-, provided that when W is -CH=, then X---Y- represents C-(CH2)p-; Z represents a divalent aliphatic hydrocarbon group; R1 and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1] .

  本发明提供了一种化合物，它具有抑制细胞因子产生的活性，可用于治疗与细胞因子有关的疾病。该化合物由以下通式（I）表示[其中 A 代表可被取代的环状基团；部分结构-D--E-代表由- -或-CH=CH-代表的基团；W 代表由-CH2-、- -、-CH=CH-或-CH=；部分结构 >X---Y- 代表由 >CH-( )n-、>C=CH-、>CH- -CH(OH)-、>CH- -C (=O) -、>CH-O- 或 >CH-O-CO- 所代表的基团，条件是当 W 为 -CH= 时，则 X---Y- 代表 C-( )p-；Z 代表二价脂肪族烃基； R1 和 R2 可以相同或不同，各自代表氢原子或羟基、烷氧基或烷氧烷氧基； m 是 0 或 1 的整数]。
• 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1501830A1

  公开（公告）日：2005-02-02