4-{2-[2-(4-cyclopropanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yloxy)-acetylamino]-thiazol-5-yloxy}-2-methyl-benzoic acid methyl ester | 1354206-67-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-{2-[2-(4-cyclopropanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yloxy)-acetylamino]-thiazol-5-yloxy}-2-methyl-benzoic acid methyl ester
• 英文别名: Methyl 4-[[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(oxan-4-yloxy)acetyl]amino]-1,3-thiazol-5-yl]oxy]-2-methylbenzoate
• CAS: 1354206-67-9
• 化学式: C₂₈H₃₀N₂O₈S₂
• 分子量: 586.687
• InChiKey: JGDUFGROFOBGLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  167
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS
  申请人：Bhuniya Debnath

  公开号：US20120214735A1

  公开（公告）日：2012-08-23

  Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

  本文披露了乙酰胺衍生物及其立体异构体、互变异构体、前药、药学上可接受的盐、多晶形、溶剂化物和制剂，用于预防、管理、治疗、控制进展或辅助治疗激活葡萄糖激酶有益的疾病和/或医疗条件。此外，本文还提供了制备这些乙酰胺衍生物的过程。
• Acetamide compounds as glucokinase activators, their process and medicinal applications
  申请人：Impetis Biosciences Ltd.

  公开号：EP2402327B1

  公开（公告）日：2018-03-07
• US9340506B2
  申请人：——

  公开号：US9340506B2

  公开（公告）日：2016-05-17