The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.
本发明提供了一种治疗或预防骨关节炎、关节积液、关节炎症和疼痛、滑膜炎、跛行、关节镜手术后、包括关节活动度在内的适当关节功能退化、减少或抑制软骨细胞的代谢活性、降解软骨的酶的活性、减少或抑制透明质酸的产生的方法,所述方法包括向哺乳动物口服治疗有效量的透明质酸或其药学上可接受的盐。此外,还公开了含有透明质酸、
硫酸软骨素和
硫酸氨基葡萄糖的膏状制剂组合物,可单独给药或用作饲料添加剂。