(Z)-5,5,5-trifluoro-4-hydroxypent-3-en-2-one | 7291-30-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-5,5,5-trifluoro-4-hydroxypent-3-en-2-one
• 英文别名: Z-1,1,1-trifluoro-4-hydroxypent-3-ene-2-one；(Z)-1,1,1-Trifluor-4-hydroxy-3-penten-2-on；1,1,1-trifluor-2,4-pentadion；trifluoroacetylacetone
• CAS: 7291-30-7
• 化学式: C₅H₅F₃O₂
• 分子量: 154.089
• InChiKey: GEGQNWRDBRXWDX-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.58
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (Z)-5,5,5-trifluoro-4-hydroxypent-3-en-2-one 以 乙醚 为溶剂， 反应 1.0h， 生成 2,2,8-Tris(trifluoromethyl)-3-trimethylsilyl-4-trimethylsilylamino-6-methyl-8-trimethylsiloxy-1,5,3λ⁵ς⁵-dioxaza-4-phosphaspiro<3.4>oct-6-en
  参考文献：
  名称：

  Seifert, Frank Uwe; Roeschenthaler, Gerd-Volker, Phosphorus, Sulfur and Silicon and the Related Elements, 1994, vol. 86, # 1-4, p. 157 - 168

  摘要：

  DOI：

文献信息

• Synthesis of fluoroalkyl-containing 1,2,3-triketone 2-hetarylhydrazones and their reactions with hydrazines
  作者：E. V. Shchegol’kov、Ya. V. Burgart、O. G. Khudina、V. I. Saloutin、O. N. Chupakhin

  DOI：10.1007/s11172-005-0158-y

  日期：2004.11

  Fluoroalkyl-containing 1,2,3-triketone 2-(2,3-dimethyl-5-oxo-1-phenyl-1,2-dihydropyrazol-4-yl)-, 2-(4-ethoxycarbonylpyrazol-3-yl)-, and 2-(1,2,4-triazol-3-yl)hydrazones were synthesized by the azo coupling reactions of fluorinated 1,3-diketones with the corresponding hetaryldiazonium chlorides. The hetarylhydrazones thus synthesized were subjected to cyclocondensation with hydrazines at the 1,3-dicarbonyl fragment to give 3-fluoroalkyl-4-hetarylazopyrazoles.

  含氟烷基的1,2,3-三酮2-(2,3-二甲基-5-氧代-1-苯基-1,2-二氢吡唑-4-基)-,2-(4-乙氧基羰基吡唑-3-基)通过氟化1,3-二酮与相应的杂芳基重氮氯化物的偶氮偶联反应合成了-、和2-(1,2,4-三唑-3-基)腙。将由此合成的杂芳基腙与肼在1，3-二羰基片段处进行环化缩合，得到3-氟烷基-4-杂芳基偶氮吡唑。
• Francke, Rudolph; Sheldrick, William S.; Roeschenthaler, Gerd-Volker, Chemische Berichte, 1989, vol. 122, p. 301 - 306
  作者：Francke, Rudolph、Sheldrick, William S.、Roeschenthaler, Gerd-Volker

  DOI：——

  日期：——
• Alyea, Elmer C.; Malek, Abdul, Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1325 - 1327
  作者：Alyea, Elmer C.、Malek, Abdul

  DOI：——

  日期：——
• Neue chemotherapeutisch-aktive 4-trifluormethylpyrimidine
  作者：Alfred Kreutzberger、Angelika Burger

  DOI：10.1016/s0022-1139(00)80040-8

  日期：1993.2

  Condensation of N-(2-hydroxyethyl)-N-methylguanidine sulfate with various beta-diketones bearing 1,1,1-trifluoromethyl substituents leads to 2-[N-(2-hydroxyethyl)-methylamino]-4-trifluoromethylpyrimidine derivatives. These compounds exhibit antimycotic, trichomonazide and anti-HIV properties.