4-[(R)-2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-3-methyl-5H-furan-2-one | 140902-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-[(R)-2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-3-methyl-5H-furan-2-one
• 英文别名: 3-[(2R)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-4-methyl-2H-furan-5-one
• CAS: 140902-59-6
• 化学式: C₁₂H₁₉NO₃
• 分子量: 225.288
• InChiKey: UVSNMKUGTFRRAQ-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.05
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.77
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-[(R)-2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-3-methyl-5H-furan-2-one 在 2,6-二甲基吡啶 、 叔丁基锂 作用下， 以 乙醚 为溶剂， 生成 (S)-4-{(R)-2-[1-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-pyrrolidin-1-yl}-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-propyl]-3,5-dimethyl-5H-furan-2-one
  参考文献：
  名称：

  An approach to erythronolide A seco acid via a simple tetronic acid

  摘要：

  The unsaturated aldehyde 1, a key intermediate in our approach to erythronolide A seco acid (2), has been prepared from the simple tetronic acid 6 by its seriatim transformations into the vinylogous urethanes 5, 9, and 11 concluding with reductive conversion of the latter into 1.

  DOI：

  10.1021/jo00037a007
• 作为产物：
  描述：

  4-羟基-3-甲基-5H-呋喃-2-酮 、 (2R)-A,A-二甲基-2-吡咯烷甲醇盐酸盐 以 xylene 为溶剂， 生成 4-[(R)-2-(1-Hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl]-3-methyl-5H-furan-2-one
  参考文献：
  名称：

  An approach to erythronolide A seco acid via a simple tetronic acid

  摘要：

  The unsaturated aldehyde 1, a key intermediate in our approach to erythronolide A seco acid (2), has been prepared from the simple tetronic acid 6 by its seriatim transformations into the vinylogous urethanes 5, 9, and 11 concluding with reductive conversion of the latter into 1.

  DOI：

  10.1021/jo00037a007