(4R)-1-bromo-1,1-difluoronon-2-yn-4-ol | 1042744-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R)-1-bromo-1,1-difluoronon-2-yn-4-ol
• CAS: 1042744-17-1
• 化学式: C₉H₁₃BrF₂O
• 分子量: 255.102
• InChiKey: INDMTQNJYXUXJW-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY
  申请人：UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

  公开号：US20150238439A1

  公开（公告）日：2015-08-27

  Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
• METHODS FOR TREATING DISEASES
  申请人：UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

  公开号：US20200108050A1

  公开（公告）日：2020-04-09

  Some embodiments of the invention include methods of using a compound such as Formula (I), Formula (II), or I-1 (e.g., in compositions or in pharmaceutical compositions) for treating diseases (e.g., cancer such as chemo-resistant cancer or cancer-therapy-resistant cancer). Additional embodiments of the invention are also discussed herein.
• US9737493B2
  申请人：——

  公开号：US9737493B2

  公开（公告）日：2017-08-22