4-Cyclopropylamino-cyclohexanol | 210685-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Cyclopropylamino-cyclohexanol
• CAS: 210685-36-2
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: XFCBWPCLGHERFF-KYZUINATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.04
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-Cyclopropylamino-cyclohexanol 、 6-[3-(1-imidazolyl)carbonylaminopropoxy]carbostyril 以 氯仿 为溶剂， 以17%的产率得到
  参考文献：
  名称：

  2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities

  摘要：

  In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido] propoxy]-2(1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00246-7
• 作为产物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以35%的产率得到4-Cyclopropylamino-cyclohexanol
  参考文献：
  名称：

  2(1H)-Quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities

  摘要：

  In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido] propoxy]-2(1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00246-7