3-(3-{4-[(3-hydroxy-phenacetyl-amino)-methyl]-benzylcarbamoyl}-pyridin-2-yloxy)-benzoic acid ethyl ester | 581772-18-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3-{4-[(3-hydroxy-phenacetyl-amino)-methyl]-benzylcarbamoyl}-pyridin-2-yloxy)-benzoic acid ethyl ester
• 英文别名: Ethyl 3-[3-[[4-[[[2-(3-hydroxyphenyl)acetyl]amino]methyl]phenyl]methylcarbamoyl]pyridin-2-yl]oxybenzoate
• CAS: 581772-18-1
• 化学式: C₃₁H₂₉N₃O₆
• 分子量: 539.588
• InChiKey: OGQZNAMAUOBDJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] MEDICAMENTS COMPRISING PDE IV INHIBITORS AND A NOVEL ANTICHOLINERGIC AND THEIR USE FOR TREATING RESPIRATORY DISORDERS<br/>[FR] MEDICAMENTS COMPRENANT DES INHIBITEURS DE PDE IV ET UN NOUVEL ANTICHOLINERGIQUE, ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES RESPIRATOIRES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2005013967A1

  公开（公告）日：2005-02-17

  The present invention relates to novel pharmaceutical compositions based on PDE IV inhibitors and salts of a new anticholinergic, processes for preparing them and their use in the treatment of respiratory complaints.

  本发明涉及基于PDE IV抑制剂和一种新的抗胆碱药盐的新型药物组合物，以及制备这些药物组合物的方法和它们在治疗呼吸道疾病中的用途。
• Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
  申请人：——

  公开号：US20030191158A1

  公开（公告）日：2003-10-09

  The invention relates to a combination of a nicotinamide derivative and tiotropium or a derivative thereof, compositions containing it and the uses of, such a combination. The combination according to the present invention is useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  这项发明涉及一种烟酰胺衍生物与噻托溴铵或其衍生物的组合，含有该组合的组合物以及该组合的用途。根据本发明的组合物在许多疾病、紊乱和症状中具有用处，特别是炎症性、过敏性和呼吸系统疾病、紊乱和症状。
• Nicotinamide derivatives useful as PDE4 inhibitors
  申请人：——

  公开号：US20030195233A1

  公开（公告）日：2003-10-16

  The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions as well as for wounds healing.

  本发明涉及烟酰胺衍生物及其制备过程、用于制备的中间体、含有该衍生物的组合物以及其用途。本发明的烟酰胺衍生物在许多疾病、疾病和病情中非常有用，特别是在炎症、过敏和呼吸系统疾病、疾病和病情以及伤口愈合方面。
• Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor
  申请人：Germeyer Sabine

  公开号：US20050043343A1

  公开（公告）日：2005-02-24

  A pharmaceutical composition comprising: (a) a compound of formula 1 wherein X 31 is an anion with a single negative charge; and (b) a PDE IV inhibitor, or an enantiomer, mixture of enantiomers, racemate, solvate, or hydrate thereof, processes for preparing them, and their use in the treatment of respiratory complaints.

  一种药物组合物，包括：(a) 公式1中X31为带有单负电荷的阴离子的化合物;以及(b) PDE IV抑制剂，或其对映体、对映体混合物、外消旋体、溶剂化物或水合物，其制备过程以及它们在治疗呼吸道疾病方面的用途。
• EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2116245A2

  公开（公告）日：2009-11-11

  The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

  本发明涉及新型药物组合物，该组合物包含至少一种表皮生长因子受体激酶抑制剂和至少另外一种选自β-2模拟物、类固醇、PDE-IV抑制剂、p38 MAP激酶抑制剂、NK1拮抗剂和内皮素拮抗剂的活性化合物；本发明还涉及组合物的制备工艺及其在治疗呼吸道或胃肠道疾病以及关节、皮肤或眼睛炎症性疾病中的用途。