2-Cyclopropyl-2-hydroxypropionamid | 98548-83-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Cyclopropyl-2-hydroxypropionamid
• 英文别名: 2-cyclopropyl-2-hydroxy-propionic acid amide；2-Cyclopropyl-2-hydroxy-propionsaeure-amid；2-Cyclopropyl-2-hydroxypropanamide
• CAS: 98548-83-5
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: SNNHDSQLHWSYHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 乙醚 作用下， 生成 2-Cyclopropyl-2-hydroxypropionamid
  参考文献：
  名称：

  Pyridylethylated Oxazolidinediones. II¹

  摘要：

  DOI：

  10.1021/ja01511a028

文献信息

• Heterocyclic cannabinoid receptor antagonists
  申请人：Mayweg Alexander

  公开号：US20050250769A1

  公开（公告）日：2005-11-10

  The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.

  本发明涉及公式I的化合物及其药用盐。这些化合物可用于治疗和/或预防与CB1受体调节相关的疾病。
• 3-Pyridinecarboxamide derivatives as HDL-cholesterol raising agents
  申请人：Andjelkovic Mirjana

  公开号：US20080085906A1

  公开（公告）日：2008-04-10

  The present invention relates to a method of raising HDL cholesterol comprising administering to a patient in need thereof a compound of the formula wherein A, G, R 1 to R 8 and R 17 are as defined in the description.

  本发明涉及一种提高HDL胆固醇的方法，包括向需要的患者施用以下公式的化合物： 其中A、G、R1至R8和R17如描述中所定义。
• Pyrazinecarboxamide derivatives as CB1 antagonists
  申请人：Hebeisen Paul

  公开号：US20070293509A1

  公开（公告）日：2007-12-20

  The present invention relates to compounds of the formula I: wherein R 1 to R 8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors, such as obesity.

  本发明涉及以下式I的化合物： 其中R1至R8如描述和索赔中定义，并且其药学上可接受的盐。这些化合物对于治疗和/或预防与调节CB1受体相关的疾病，如肥胖症，是有用的。
• Isoxazolo derivatives
  申请人：Buettelmann Bernd

  公开号：US20070066668A1

  公开（公告）日：2007-03-22

  The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula wherein R 1 , R 2 , R 3 , R 4 , and R 5 , and m are as defined herein and with their pharmaceutically acceptable acid addition salts. This class of compounds have high affinity and selectivity for GABA A α5 receptor binding sites and therefore may be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

  本发明涉及一种芳基异噁唑-4-甲酰基-吡咯-2-羧酸酰胺衍生物，其化学式为其中R1、R2、R3、R4和R5以及m的定义如本文所述，并且涉及它们的药学上可接受的酸盐。这类化合物具有高亲和力和选择性，可结合到GABA A α5受体结合位点，因此可能用作认知增强剂或用于治疗像阿尔茨海默病这样的认知障碍。
• 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS
  申请人：Hebeisen Paul

  公开号：US20090247550A1

  公开（公告）日：2009-10-01

  The present invention relates to pyrazine derivatives of the formula and pharmaceutically acceptable salts thereof, wherein R 1 to R 8 are as defined in the description and claims for use as HDL-cholesterol raising agents in the treatment and/or prophylaxis of diseases or disorders that can be treated with such agents such as dyslipidemia.

  本发明涉及式中的吡嗪衍生物及其药学上可接受的盐，其中R1至R8在说明书和权利要求书中定义，用作提高高密度脂蛋白胆固醇的药物，用于治疗和/或预防可以用这种药物治疗的疾病或疾病，如脂质代谢紊乱。