2,2-二甲基辛酰胺 | 103906-30-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,2-二甲基辛酰胺
• 英文名称: 2,2-dimethyloctanamide
• 英文别名: 2,2-Dimethyl-octansaeure-amid；2.2-Dimethyl-caprylsaeure-amid；2,2-dimethyl-octanoic acid amide；2-Methyl-octan-carbonsaeure-(2)-amid；dimethyloctamide；Dimethyloctanamid
• CAS: 103906-30-5
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: FITYLPBGJXBNCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-二甲基辛酰胺 在 [双(三氟乙酰氧基)碘]苯 作用下， 以 水 、 乙腈 为溶剂， 反应 12.0h， 生成 2-甲基-2-辛胺
  参考文献：
  名称：

  Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

  摘要：

  An extended series of alkyl carboxamide analogs of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716; 5) was synthesized. Each compound was tested for its ability to displace the prototypical cannabinoid ligands ([H-3]CP-55,940, [H-3]2; [H-3]SR141716, [H-3]5; and [H-3]WIN55212-2, [H-3]3), and selected compounds were further characterized by determining their ability to affect guanosine 5'-triphosphate (GTP)-gamma-[S-35] binding and their effects in the mouse vas deferens assay. This systematic evaluation has resulted in the discovery of novel compounds with unique binding properties at the central cannabinoid receptor (CB1) and distinctive pharmacological activities in CB I receptor tissue preparations. Specifically, compounds with nanomolar affinity which are able to fully displace [H-3]5 and [H-3]2, but unable to displace [3 H]3 at similar concentrations, have been synthesized. This selectivity in ligand displacement is unprecedented, in that previously, compounds in every structural class of cannabinoid ligands had always been shown to displace each of these radioligands in a competitive fashion. Furthermore, the selectivity of these compounds appears to impart unique pharmacological properties when tested in a mouse vas deferens assay for CB1 receptor antagonism. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2005.06.005
• 作为产物：
  描述：

  2,2-二甲基辛酸 在 氯化亚砜 、 氨 、 水 作用下， 生成 2,2-二甲基辛酰胺
  参考文献：
  名称：

  Synthesis of 2,2-Dimethylalkanoic Acids from Ethylene

  摘要：

  DOI：

  10.1021/ja01164a020

文献信息

• Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof
  申请人：Ghosh Arun K.

  公开号：US20080125467A1

  公开（公告）日：2008-05-29

  The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.

  本发明提供了新型β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默病的方法。
• [EN] BENAZOLIN-CHOLINE AND ITS USE IN THE AGROCHEMICAL FIELD<br/>[FR] BÉNAZOLINE-CHOLINE ET SON UTILISATION DANS LE DOMAINE AGROCHIMIQUE
  申请人：BAYER AG

  公开号：WO2021028375A1

  公开（公告）日：2021-02-18

  The present invention relates to the technical field of crop protection. More specifically, the present invention relates to benazolin-choline and to compositions (formulations) comprising benazolin-choline. The invention also relates to methods of manufacturing benazolin-choline and compositions comprising benazolin-choline as well as uses thereof.

  本发明涉及作物保护技术领域。更具体地说，本发明涉及苯唑啉-氯化胆碱以及包含苯唑啉-氯化胆碱的组合物（配方）。该发明还涉及制造苯唑啉-氯化胆碱和包含苯唑啉-氯化胆碱的组合物的方法，以及它们的用途。
• [EN] PROCESS OF SYNTHESIZING AND PURIFYING (3R)-HYDROXYBUTYL (3R)-HYDROXYBUTANOATE<br/>[FR] PROCÉDÉ DE SYNTHÈSE ET DE PURIFICATION DE (R)-3-HYDROXYBUTANOATE DE (R)-3-HYDROXYBUTYLE
  申请人：GENOMATICA INC

  公开号：WO2021231271A1

  公开（公告）日：2021-11-18

  A process for synthesizing (R)-3 -hy droxybutyl (R)-3 -hy droxybutanoate from ethyl (R)-3-hydroxybutanoate and (R)-l,3-butanediol, as well a process for synthesizing (R)-3-hy droxybutyl (R)-3-hy droxybutanoate from (R)-3-hydroxybutyric acid and (R)-l,3-butanediol. Also provided are processes for isolating (R)-3-hy droxybutyl (R)-3-hy droxybutanoate, including from a fermentation broth.

  从乙酸(R)-3-羟基丁酸和(R)-1,3-丁二醇合成(R)-3-羟丁酸(R)-3-羟丁酯的过程，以及从(R)-3-羟基丁酸和(R)-1,3-丁二醇合成(R)-3-羟基丁酸(R)-3-羟基丁酯的过程。还提供了从发酵液中分离(R)-3-羟基丁酸(R)-3-羟基丁酯的过程。
• Stain-proofing agent containing a polyfluoroalkyl group, and process for its preparation
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0103752A2

  公开（公告）日：1984-03-28

  A stainproofing agent containing as an active ingredient a polyfluoroalkyl group-containing compound represented by the following general formula and having a molecular weight of from 800 to 3000: where R, is a polyfluoroalkyl group having from 1 to 20 carbon atoms, X is-R-, -CON(R1)-Q- or-SO2N(R1)-Q- (where R is a divalent alkylene group, R' is a hydrogen atom or a lower alkyl group and Q is a divalent organic group), each of A and A' is -0-, -S- or -N(Z')- (where Z' is a hydrogen atom or a monovalent organic group), Z is a monovalent organic group, W is a trivalent organic group, a is an integer of 1, or 3. A process for the stainproofing agent is also disclosed.

  一种防污剂，其活性成分是由下式通式表示的含多氟烷基的化合物，分子量为 800 至 3000： 其中 R 是具有 1 至 20 个碳原子的多氟烷基，X 是-R-、-CON(R1)-Q- 或-SO2N(R1)-Q-（其中 R 是二价亚烷基，R'是氢原子或低级烷基，Q 是二价有机基团）、A和A'各自为-0-、-S-或-N(Z')-（其中Z'为氢原子或一价有机基团），Z为一价有机基团，W为三价有机基团，a为1或3的整数。还公开了一种防污剂的工艺。
• High performance water and oil repellant
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0218909A2

  公开（公告）日：1987-04-22

  A high performance water and oil repellant composed of a compound comprising at least two terminal segments and an intermediate segment connecting the terminal segments and having a molecular weight of from 800 to 20,000, each terminal segment containing at least one polyfluoroalkyl group connected by a -CONH-linking group, said intermediate segment being a urethane oligomer containing at least two -CONH-linking groups in one molecule, and said terminal segments and intermediate segment being connected by a -CONH-linking group.

  一种高性能防水防油剂，由一种化合物组成，该化合物包含至少两个末端区段和连接末端区段的中间区段，分子量在 800 到 20,000 之间，每个末端区段包含至少一个由-CONH-连接基团连接的多氟烷基，所述中间区段是一个聚氨酯低聚物，在一个分子中包含至少两个-CONH-连接基团，所述末端区段和中间区段由-CONH-连接基团连接。