1-[5-[[5-(2-Hydroxyethylsulfanyl)-3-(2-methylpyridin-3-yl)oxypyridin-2-yl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol | 1138670-74-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[5-[[5-(2-Hydroxyethylsulfanyl)-3-(2-methylpyridin-3-yl)oxypyridin-2-yl]amino]-1,2,4-thiadiazol-3-yl]ethane-1,2-diol
• CAS: 1138670-74-2
• 化学式: C₁₇H₁₉N₅O₄S₂
• 分子量: 421.501
• InChiKey: REVBYCNXEFJPIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  187
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS
  申请人：Array Biopharma, Inc.

  公开号：EP2209778A1

  公开（公告）日：2010-07-28
• [EN] PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS<br/>[FR] ACTIVATEURS DE GLUCOKINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2009042435A1

  公开（公告）日：2009-04-02

  Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.