2-Oxepanone, 5,5'-(1-methylethylidene)bis- | 93745-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-Oxepanone, 5,5'-(1-methylethylidene)bis-
• 英文别名: 5-[2-(7-oxooxepan-4-yl)propan-2-yl]oxepan-2-one
• CAS: 93745-78-9
• 化学式: C₁₅H₂₄O₄
• 分子量: 268.35
• InChiKey: HCFNCJMSWOAVTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• STAR POLYMERS, METHODS OF PREPARATION THEREOF, AND USES THEREOF
  申请人：Appel Eric Andrew

  公开号：US20110243848A1

  公开（公告）日：2011-10-06

  A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million.

  一种物质组成，包括一个两性星型聚合物，该星型聚合物包括一个交联的微胶核和6个或更多独立的聚合物臂，这些聚合物臂共价连接到核心，这6个或更多的臂每个包括一个亲水性聚合物链段和一个疏水性聚合物链段。其中，从铍、镁、钙、锶、钡、镭、铝、镓、铟、铊、锗、锡、铅、砷、锑、铋、碲、钋和周期表3到12组的金属中选择的每种单个金属在星型聚合物中的浓度大于或等于0ppm并小于或等于100ppm。
• Polyester nanogel core star polymers for delivery of therapeutic agents
  申请人：International Business Machines Corporation

  公开号：US10392470B2

  公开（公告）日：2019-08-27

  Amphiphilic star polymers were prepared having superior loading properties for delivery of hydrophobic biologically active materials intended for use in medical, cosmetic, and other applications. The star polymers comprise a plurality block copolymer arms linked to a crosslinked polyester core. The monovalent arms comprise a peripheral poly(ethylene oxide) block (PEG block) and a polyester block, which is linked to the core. The sidechain substituents of the polyester block substantially improve the loading capacity of the star polymer for CoQ10 and other hydrophobic materials.

  制备出的两亲星型聚合物具有优异的负载性能，可用于输送疏水性生物活性材料，供医疗、化妆品和其他应用使用。星型聚合物由多个嵌段共聚物臂组成，嵌段共聚物臂与交联聚酯芯相连。单价臂包括外围的聚环氧乙烷嵌段（PEG 嵌段）和与核心相连的聚酯嵌段。聚酯嵌段的侧链取代基大大提高了星形聚合物对 CoQ10 和其他疏水性材料的负载能力。
• Co-delivery of cholesterol lowering drugs and nutraceuticals
  申请人：International Business Machines Corporation

  公开号：US10457759B2

  公开（公告）日：2019-10-29

  Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.

  制备的星形聚合物闭塞复合物包括 i) 两性单分子星形聚合物，其交联核心与 6 个或更多独立的两性聚合物臂共价连接；ii) 营养保健品（如辅酶 Q10）；iii) 降胆固醇药物（如辛伐他汀）。营养保健品与星形聚合物形成的初始闭塞复合物对降低胆固醇药物的结合性能有所改善，从而提高了降低胆固醇药物的装载效率。星形聚合物闭塞复合物可用于治疗高血脂。
• JPH08119960A
  申请人：——

  公开号：JPH08119960A

  公开（公告）日：1996-05-14
• STAR POLYMER NANOSHELLS AND METHODS OF PREPARATION THEREOF
  申请人：Lee Victor Yee-Way

  公开号：US20120237447A1

  公开（公告）日：2012-09-20

  A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.