N-[5-tert-Butyl-3-(3-{4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide | 476010-74-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[5-tert-Butyl-3-(3-{4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yloxy]-naphthalen-1-yl}-ureido)-2-methoxy-phenyl]-methanesulfonamide
• 英文别名: 1-[5-Tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-3-[4-[2-[2-(dimethylamino)ethylamino]pyrimidin-4-yl]oxynaphthalen-1-yl]urea
• CAS: 476010-74-9
• 化学式: C₃₁H₃₉N₇O₅S
• 分子量: 621.761
• InChiKey: QLMSCZUYVIIYSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Compounds useful as anti-inflammatory agents
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030008868A1

  公开（公告）日：2003-01-09

  Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

  公开了一些化合物，可用于制备用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病的药物组合物。还公开了制备这些化合物的方法。
• DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1392661A1

  公开（公告）日：2004-03-03
• US6852717B2
  申请人：——

  公开号：US6852717B2

  公开（公告）日：2005-02-08
• [EN] DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS<br/>[FR] DERIVES DE DIARYLUREE UTILISABLES EN TANT QU'AGENTS ANTI-INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002092576A1

  公开（公告）日：2002-11-21

  Disclosed are diarylurea derivatives useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.