L-ribose 2,3,4,5-tetraacetate | 192133-11-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-ribose 2,3,4,5-tetraacetate
• 英文别名: [(2S,3S,4S)-2,3,4-triacetyloxy-5-oxopentyl] acetate
• CAS: 192133-11-2
• 化学式: C₁₃H₁₈O₉
• 分子量: 318.281
• InChiKey: ZYPMNZKYVVSXOJ-FRRDWIJNSA-N

物化性质

• 熔点：
  109.5-110 °C
• 沸点：
  410.2±45.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  L-ribose 2,3,4,5-tetraacetate 在 硫酸 、 potassium carbonate 作用下， 以 吡啶 、 乙醇 、 溶剂黄146 为溶剂， 生成 1-乙酰氧基-2,3,5-三苯甲酰氧基-β-L-呋喃核糖
  参考文献：
  名称：

  Synthesis and Testing of New Modified Nucleosides

  摘要：

  New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-e and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analgoues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.

  DOI：

  10.1080/15257779908041490
• 作为产物：
  描述：

  5-O-三苯甲基-D-呋喃核糖 在 sodium tetrahydroborate 、 甲酸 、 三乙胺 、 三氟乙酸酐 作用下， 以 吡啶 、 水 、 二甲基亚砜 为溶剂， 反应 2.12h， 生成 L-ribose 2,3,4,5-tetraacetate
  参考文献：
  名称：

  Synthesis and Testing of New Modified Nucleosides

  摘要：

  New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-e and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analgoues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.

  DOI：

  10.1080/15257779908041490

文献信息

• NEURITE OUTGROWTH AGENT
  申请人：Kaminishi Hidenori

  公开号：US20130102771A1

  公开（公告）日：2013-04-25

  An object of the present invention is to provide a non-peptidic nerve axon and/or neurite outgrowth agent for allowing a nerve axon and a neurite to elongate. 3-(Aminocarbonyl)-1-[5-O-[[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranos-5-O-yl]phosphonyloxy(oxylato)phosphinyl]-β-L-ribofuranosyl]pyridinium that is an analogue of nicotinamide adenine dinucleotide (NAD) comprising β-L-ribose as the sugar component is used as a nerve axon and/or neurite outgrowth agent or composition, a cancer cell growth suppressing and/or apoptosis inducing agent, or a cancer cell growth suppressing and/or apoptosis inducing composition.

  本发明的目的是提供一种非肽类神经轴突和/或神经元突出生剂，以使神经轴突和神经元突得以延长。使用3-（氨基羰基）-1- [5-O- [[1-（6-氨基-9H-嘌呤-9-基）-1-脱氧-β-D-核糖呋喃-5-O-基]磷酸酯（氧酸）磷酸酯]-β-L-核糖呋喃基]吡啶铵，它是尼克酰胺腺嘌呤二核苷酸（NAD）的类似物，包括β-L-核糖糖作为糖成分，作为神经轴突和/或神经元突出生剂或组合物，癌细胞生长抑制和/或诱导细胞凋亡剂，或癌细胞生长抑制和/或诱导细胞凋亡组合物。
• VISUAL FUNCTION IMPROVEMENT AGENT, AND METHOD FOR IMPROVING VISUAL FUNCTION
  申请人：Tanaka, Megumi

  公开号：EP3513795A1

  公开（公告）日：2019-07-24

  PROBLEM: To provide an improving agent and an improving method for a visual function that is safe in long-term intake and ensures effective improvement of the visual function. SOLUTION: Nicotinamide mononucleotide is contained as an active ingredient.

  问题：提供一种长期服用安全并能确保有效改善视觉功能的视觉功能改善剂和改善方法。 解决方案：含有烟酰胺单核苷酸作为活性成分。
• SLEEP DISORDER IMPROVEMENT AGENT AND METHOD FOR IMPROVING SLEEP DISORDERS
  申请人：Tanaka, Megumi

  公开号：EP3513796A1

  公开（公告）日：2019-07-24

  PROBLEM: To provide an improving agent and an improving method for a sleep disorder that is safe in long-term intake and ensures effective improvement of the sleep disorder. SOLUTION: Nicotinamide mononucleotide is contained as an active ingredient.

  问题：提供一种改善睡眠障碍的药剂和改善方法，长期服用安全，并确保有效改善睡眠障碍。 解决方案：含有烟酰胺单核苷酸作为活性成分。
• AGENT FOR ACCELERATING GROWTH OF STEM CELLS WITH DIFFERENTIATION POTENTIAL
  申请人：Oriental Yeast Co., Ltd.

  公开号：EP3578639A1

  公开（公告）日：2019-12-11

  An object of the present invention is to provide a material capable of further accelerating growth of pluripotent stem cells, such as pluripotent stem cells, without impairing pluripotency thereof. In other words, the invention is an agent for accelerating growth of pluripotent stem cells, containing a β-nicotinamide mononucleotide or a pharmaceutically acceptable salt thereof, and a solvate thereof as an active ingredient; and is a method for culturing pluripotent stem cells, including culturing pluripotent stem cells in a culture medium that contains a β-nicotinamide mononucleotide or a pharmaceutically acceptable salt thereof, and a solvate thereof.

  本发明的目的是提供一种能够进一步加速多能干细胞（如多能干细胞）生长而不损害其多能性的材料。换句话说，本发明是一种加速多能干细胞生长的制剂，其活性成分含有β-烟酰胺单核苷酸或其药学上可接受的盐，以及其溶液；本发明还是一种培养多能干细胞的方法，包括在含有β-烟酰胺单核苷酸或其药学上可接受的盐，以及其溶液的培养基中培养多能干细胞。
• ANTI-AGING AGENT AND ANTI-AGING METHOD
  申请人：Tanaka, Megumi

  公开号：EP3682746A1

  公开（公告）日：2020-07-22

  PROBLEM: To provide an anti-aging agent and a method for the anti-aging that are safe in long-term intake and ensures effective suppression of the progress of the aging. SOLUTION: Nicotinamide mononucleotide is contained as an active ingredient.

  问题：提供一种抗衰老剂和一种抗衰老方法，这种抗衰老剂和方法长期服用是安全的，并能确保有效抑制衰老的进展。解决方案：含有烟酰胺单核苷酸作为活性成分。