4-methoxy-1,9-di-(2-tetrahydropyranyloxy)-dec-5-yne | 213040-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4-methoxy-1,9-di-(2-tetrahydropyranyloxy)-dec-5-yne
• CAS: 213040-07-4
• 化学式: C₂₁H₃₆O₅
• 分子量: 368.514
• InChiKey: LYTGYPSUMVEICL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.04
• 重原子数：
  26.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  46.15
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-methoxy-1,9-di-(2-tetrahydropyranyloxy)-dec-5-yne 在 六甲基磷酰三胺 、 copper(I) bromide dimethylsulfide complex 作用下， 以 乙醚 为溶剂， 生成 8-tert-butyl-tetradeca-6,7-diene-1,1-diyne
  参考文献：
  名称：

  Synthesis of variously substituted allenediynes and their cobalt (I)-mediated [2+2+2] cycloaddition reactions

  摘要：

  Syntheses of variously substituted allenediynes where the allene moiety is at the terminal or internal position are described. Their cobalt(I)-mediated [2+2+2] cycloaddition reactions led to the corresponding eta(4)-complexed tricyclic compounds; the regioselectivity of these cyclizations depending on the substitution and the position of the allene is discussed. (C) 1998 Elsevier Science Ltd. Ali rights reserved.

  DOI：

  10.1016/s0040-4020(98)00567-5
• 作为产物：
  描述：

  4-(四氢-2H-吡喃-2-基氧基)丁醛 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.67h， 生成 4-methoxy-1,9-di-(2-tetrahydropyranyloxy)-dec-5-yne
  参考文献：
  名称：

  Synthesis of variously substituted allenediynes and their cobalt (I)-mediated [2+2+2] cycloaddition reactions

  摘要：

  Syntheses of variously substituted allenediynes where the allene moiety is at the terminal or internal position are described. Their cobalt(I)-mediated [2+2+2] cycloaddition reactions led to the corresponding eta(4)-complexed tricyclic compounds; the regioselectivity of these cyclizations depending on the substitution and the position of the allene is discussed. (C) 1998 Elsevier Science Ltd. Ali rights reserved.

  DOI：

  10.1016/s0040-4020(98)00567-5