7-[2-[(2,3-Dimethylbenzimidazol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]oxy-2,3-dihydroinden-1-one | 1227948-60-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-[2-[(2,3-Dimethylbenzimidazol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]oxy-2,3-dihydroinden-1-one
• CAS: 1227948-60-8
• 化学式: C₂₃H₁₈F₃N₅O₂
• 分子量: 453.423
• InChiKey: HVQGHRBZADHNIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.9
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF DISEASES SUCH AS CANCER
  申请人：Stadtmueller Heinz

  公开号：US20110288071A1

  公开（公告）日：2011-11-24

  The present invention encompasses compounds of general formula (1) wherein A, B, X, R 1 to R 3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖通式（1）中A，B，X，R1至R3如权利要求1所定义的化合物，适用于治疗由过度或异常细胞增殖特征的疾病，并用于制备具有上述特性的药物。
• NEW COMPOUNDS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160362404A1

  公开（公告）日：2016-12-15

  The present invention encompasses compounds of general formula (1) wherein A, B, X, R l to R 3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
• US8846689B2
  申请人：——

  公开号：US8846689B2

  公开（公告）日：2014-09-30
• US9676762B2
  申请人：——

  公开号：US9676762B2

  公开（公告）日：2017-06-13