(3S,3aR,4S,7aR)-2,3-dibenzyl-6-methyl-1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester | 459832-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (3S,3aR,4S,7aR)-2,3-dibenzyl-6-methyl-1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester
• 英文别名: (3S,3AR,4S,7AR)-1,2,3,3a,4,7a-hexahydro-6-methyl-1-oxo-2,3-bis(phenylmethyl)-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester；ethyl (3S,3aR,4S,7aR)-2,3-dibenzyl-6-methyl-1-oxo-3,3a,4,7a-tetrahydropyrano[3,4-c]pyrrole-4-carboxylate
• CAS: 459832-87-2
• 化学式: C₂₅H₂₇NO₄
• 分子量: 405.494
• InChiKey: ZVKKNDJIXZOSNU-GPJHCHHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S,3aR,4S,7aR)-2,3-dibenzyl-6-methyl-1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester 在 水 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以78%的产率得到ethyl (2S)-2-[(2S,3R,4S)-1,2-dibenzyl-5-oxo-4-(2-oxopropyl)pyrrolidin-3-yl]-2-hydroxyacetate
  参考文献：
  名称：

  Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels–Alder reaction

  摘要：

  Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functionalized bi or polycyclic compounds. We discovered that trienes 6a-j undergo facile stereoselective intramolecular Diels-Alder reactions to generate densely functionalized cis fused pyrrolidinone templates 1a-j. These reactions allow for directed remote hydroxylation with complete control of stereochemistry. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01711-2
• 作为产物：
  描述：

  BOC-PHE-甲氧基甲胺 在 lithium aluminium tetrahydride 、 N-羟基-7-氮杂苯并三氮唑 、 potassium tert-butylate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 16.0h， 生成 (3S,3aR,4S,7aR)-2,3-dibenzyl-6-methyl-1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels–Alder reaction

  摘要：

  Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functionalized bi or polycyclic compounds. We discovered that trienes 6a-j undergo facile stereoselective intramolecular Diels-Alder reactions to generate densely functionalized cis fused pyrrolidinone templates 1a-j. These reactions allow for directed remote hydroxylation with complete control of stereochemistry. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01711-2

文献信息

• An intramolecular oxo Diels–Alder approach to 1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters
  作者：William V Murray、Pranab K Mishra、Ignatius J Turchi、Dorota Sawicka、Amy Maden、Sengen Sun

  DOI：10.1016/j.tet.2003.04.007

  日期：2003.11

  The diastereoselective synthesis of a series of 1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters via an oxo Diels-Alder reaction is described. Ab initio calculations predicted the products of the exo cycloaddition to be the thermodynamic products while the products resulting from the endo cycloaddition were predicted to be the kinetic products. The calculations were born out by experimental data. (C) 2003 Elsevier Ltd. All rights reserved.
• US6512120B1
  申请人：——

  公开号：US6512120B1

  公开（公告）日：2003-01-28