9-carbamoyl-nonanoic acid ethyl ester | 91694-66-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-carbamoyl-nonanoic acid ethyl ester
• 英文别名: 9-Carbamoyl-nonansaeure-aethylester；Ethyl 10-amino-10-oxodecanoate；ethyl 10-amino-10-oxodecanoate
• CAS: 91694-66-5
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: KVWFMMLABJSWAR-UHFFFAOYSA-N

物化性质

• 熔点：
  68-69 °C
• 沸点：
  372.5±25.0 °C(Predicted)
• 密度：
  0.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-carbamoyl-nonanoic acid ethyl ester 在 乙醇 、 羟胺 、 sodium ethanolate 作用下， 生成 N-hydroxy-decanediamide
  参考文献：
  名称：

  Synthesis of Some Hydroxamic Acids. Reactivity with Isopropyl Methylphosphonofluoridate (GB)

  摘要：

  DOI：

  10.1021/jo01092a027
• 作为产物：
  描述：

  癸二酸氯化乙酯 在 氨 作用下， 生成 9-carbamoyl-nonanoic acid ethyl ester
  参考文献：
  名称：

  Flaschentraeger, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1926, vol. 159, p. 304

  摘要：

  DOI：

文献信息

• [EN] AROMATIC GUANYLHYDRAZONES AS EFFECTIVE COMPOUNDS AGAINST NEURODISEASES<br/>[FR] GUANYLHYDRAZONES AROMATIQUES UTILISES COMME COMPOSES EFFICACES CONTRE LES MALADIES NERVEUSES
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2003006426A1

  公开（公告）日：2003-01-23

  The present invention provides novel aromatic guanylhydrazone compounds and relates to the use of a class of aromatic guanylhydrazones compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of neurodiseases such as addiction, alzheimer's disease, anxiety disorders, autism, blindness, cerebral palsy, chronic fatigue syndrome, Chorea Huntington, depression, dyslexia, epilepsy, infectious diseases, prion diseases, prion infections, multiple sclerosis, muscular dystrophy, neurology, neurotoxicities, pain, parkinson's disease, schizophrenia, sleep disorders, stress, stroke, tourette syndrome, and tumors. Furthermore, the present invention relates to pharmaceutical compositions containing at least one aromatic guanylhydrazone compound and/or pharmaceutically acceptable salt thereof. These pharmaceutical compositions can be used within methods for preventing and/or treating neurological and/or mental diseases, especially prion infections and prion diseases.
• Synthesis of Some Hydroxamic Acids. Reactivity with Isopropyl Methylphosphonofluoridate (GB)
  作者：G. F. ENDRES、JOSEPH EPSTEIN

  DOI：10.1021/jo01092a027

  日期：1959.10
• Flaschentraeger, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1926, vol. 159, p. 304
  作者：Flaschentraeger

  DOI：——

  日期：——