6-硒基鸟苷 | 29411-74-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 6-硒基鸟苷
• 英文名称: 2-(2-amino-6-λ¹-selanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 英文别名: 6-seleno-guanosine
• CAS: 29411-74-3
• 化学式: C₁₀H₁₃N₅O₄Se
• 分子量: 346.204
• InChiKey: JEWAOLSIJOZQMU-UUOKFMHZSA-N

物化性质

• 沸点：
  781.5±70.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  142.44
• 氢给体数：
  5.0
• 氢受体数：
  8.0

安全信息

• 危险品运输编号：
  UN 3283 6.1/PG 3
• 危险类别码：
  R23/24/25

文献信息

• Oxidative Degradation of 6-Selenoguanosine in Aqueous Solutions
  作者：A.J. Repta、Y.A. Beltagy

  DOI：10.1002/jps.2600700615

  日期：1981.6

  The degradation of 6-selenoguanosine (NSC 137679) (I) in water and in various buffer systems was investigated. Drug degradation in aqueous media was monitored by high-pressure of I in various chromatography. Some kinetic aspects of the degradation of I in various buffer systems at 25 degrees also were studied spectrophotometrically. The degradation, which requires oxygen, involves autoxidation of I

  研究了6-硒代鸟苷（NSC 137679）（I）在水中和各种缓冲液系统中的降解情况。在各种色谱法中，通过高压I监测水性介质中的药物降解。分光光度法还研究了在25度下在各种缓冲系统中I降解的一些动力学方面。需要氧气的降解涉及将I自动氧化为相应的二硒化物，在氧气存在下生成硒化物和金属硒。该降解途径与报道的有关硫代化合物的氧化途径不同。
• Selenium-containing platinum compound
  申请人：——

  公开号：US04536571A1

  公开（公告）日：1985-08-20

  The toxic effects of platinum compounds used in chemotherapy can be negated by the use of a selenium-containing compound. A new selenium-containing platinum compound has been found to be useful as a so-called platinum compound type anti-cancer medicine which can self-detoxify platinum toxicity.

  使用化疗中的铂化合物可能会产生毒性影响，但使用含硒化合物可以抵消这种影响。一种新的含硒铂化合物已被发现可用作所谓的铂化合物类抗癌药物，可以自我解毒铂毒性。
• Antioxidants in purification, stabilization, and formulation of the antineoplastic agent 6-selenoguanosine
  作者：Y.A. Beltagy、W. Waugh、A.J. Repta

  DOI：10.1002/jps.2600691012

  日期：1980.10

  6-Selenoguanosine (NSC 137679) was stablized and formulated as a lyophilized parenteral paroduct using ascorbic acid as an antioxidant. In addition to preventing the oxidation of 6-selenoguanosine to the corresponding diselenide in aqueous solution, ascorbic acid reduced the diselenide already in the bulk drug. Dithioerythritol and sodium bisulfite also were evaluated as antioxidants. Dithioerythritol

  使用抗坏血酸作为抗氧化剂，稳定化6-硒代鸟苷（NSC 137679），制成冻干的肠胃外产品。除了防止6-硒代鸟苷在水溶液中氧化为相应的二硒化物外，抗坏血酸还可以还原散装药物中的二硒化物。还评价了二硫赤藓糖醇和亚硫酸氢钠作为抗氧化剂。二硫赤藓糖醇的作用类似于抗坏血酸，而亚硫酸氢钠与6-硒代鸟苷迅速反应。
• Scovill, John P., Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 70, # 1/2, p. 1 - 2
  作者：Scovill, John P.

  DOI：——

  日期：——