| 1186073-97-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1186073-97-1
• 化学式: C₃₇H₅₁IN₄O₇S
• 分子量: 822.805
• InChiKey: ILYDOANGQIWHAH-NYTTUPTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.85
• 重原子数：
  50.0
• 可旋转键数：
  15.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  108.21
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  在 hexaammonium heptamolybdate tetrahydrate 、 双氧水 作用下， 以 乙醇 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  Total Synthesis of (+)-Sorangicin A

  摘要：

  The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity. Critical to the final-stage success was the use of a carefully defined Stille coupling and a Mukaiyama macrolactonization as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomerization and/or destruction of the delicate (Z,Z,E)-trienoate linkage.

  DOI：

  10.1021/ja906115a
• 作为产物：
  描述：

  (E)-5-((4S,5R)-5-((2R,4S,5S,6R)-6-((E)-3-((1R,3S,4R,5R,7R)-7-((E)-2-iodovinyl)-4-methyl-2,6-dioxabicyclo[3.2.1]octan-3-yl)allyl)-4-(methoxymethoxy)-5-methyltetrahydro-2H-pyran-2-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-4-en-1-ol 、 1-苯基-5-巯基四氮唑 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 0.75h， 以93%的产率得到
  参考文献：
  名称：

  Total Synthesis of (+)-Sorangicin A

  摘要：

  The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity. Critical to the final-stage success was the use of a carefully defined Stille coupling and a Mukaiyama macrolactonization as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomerization and/or destruction of the delicate (Z,Z,E)-trienoate linkage.

  DOI：

  10.1021/ja906115a