(4-imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid | 913173-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (4-imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid
• 英文别名: 2-(4-imidazo[4,5-c]pyridin-1-ylphenyl)acetic acid
• CAS: 913173-45-2
• 化学式: C₁₄H₁₁N₃O₂
• 分子量: 253.26
• InChiKey: JGQATXWQVBAMEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid 、 间氨基三氟甲苯 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-(4-imidazo[4,5-c]pyridin-1-yl-phenyl)-N-(3-trifluoromethyl-phenyl)-acetamide
  参考文献：
  名称：

  WO2008/46802

  摘要：

  公开号：

文献信息

• Phenylacetamides Suitable as Protein Kinase Inhibitors
  申请人：Bold Guido

  公开号：US20080319005A1

  公开（公告）日：2008-12-25

  The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

  本发明涉及公式(I)的化合物，其中基团R1、R2、R3、R9、R10和Q以及X、Y和Z的定义如规范中所述，以及其盐，以及它们的使用、使用方法和合成方法等。这些化合物是蛋白激酶抑制剂，可以用于治疗各种增生性疾病。
• Phenylacetamides being FLT3 Inhibitors
  申请人：Furet Pascal

  公开号：US20100075980A1

  公开（公告）日：2010-03-25

  Compounds of formula wherein the residues R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, salts thereof; their use, methods of their use, processes for their production, pharmaceutical compositions comprising them, their combinations with second drug substances and the use thereof and the like. The compounds are protein kinase inhibitors and can be used for the treatment of diseases mediated by protein kinase inhibitors, e.g. for the treatment of various proliferative diseases.

  该专利涉及公式中残基R1、R2、R3、R9、R10和Q以及X、Y和Z的化合物，其盐；它们的使用，使用方法，生产过程，包含它们的制药组合物，它们与第二药物物质的组合及其使用等。这些化合物是蛋白激酶抑制剂，可用于治疗由蛋白激酶抑制剂介导的疾病，例如用于治疗各种增殖性疾病。
• Phenylacetamides being FLT3 inhibitors
  申请人：Novartis AG

  公开号：US07977338B2

  公开（公告）日：2011-07-12

  Compounds of formula wherein the residues R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, salts thereof; their use, methods of their use, processes for their production, pharmaceutical compositions comprising them, their combinations with second drug substances and the use thereof and the like. The compounds are protein kinase inhibitors and can be used for the treatment of diseases mediated by protein kinase inhibitors, e.g. for the treatment of various proliferative diseases.

  该文本的翻译如下： 化合物的公式为其中残基R1、R2、R3、R9、R10和Q以及X、Y和Z的定义如规范中所述，它们的盐；它们的使用、使用方法、生产过程、包含它们的药物组合物、它们与第二药物物质的组合以及它们的使用等。这些化合物是蛋白激酶抑制剂，可用于治疗通过蛋白激酶抑制剂介导的疾病，例如用于治疗各种增殖性疾病。
• PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS
  申请人：BOLD Guido

  公开号：US20120184561A1

  公开（公告）日：2012-07-19

  The invention relates to compounds of the formula I, wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof; as well as their use, methods of use for them and methods of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

  本发明涉及公式I的化合物，其中基团R1、R2、R3、R9、R10和Q以及X、Y和Z如规范中所定义，并且它们的盐；以及它们的用途，使用方法和合成方法等。这些化合物是蛋白激酶抑制剂，可以用于治疗各种增殖性疾病。
• Phenylacetamides suitable as protein kinase inhibitors
  申请人：Novartis AG

  公开号：US08030311B2

  公开（公告）日：2011-10-04

  The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

  本发明涉及式(I)化合物，其中基团R1、R2、R3、R9、R10和Q以及X、Y和Z如规范中所定义，并且其盐，以及它们的使用，使用方法和合成方法等。这些化合物是蛋白激酶抑制剂，可以用于治疗各种增殖性疾病。