5-phenyl-4-(piperidin-1-yl)-6H-benzo[b]tetrazolo[1,5-d][1,4]diazepine | 1383606-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-phenyl-4-(piperidin-1-yl)-6H-benzo[b]tetrazolo[1,5-d][1,4]diazepine
• CAS: 1383606-15-2
• 化学式: C₂₀H₂₀N₆
• 分子量: 344.419
• InChiKey: HBSUOSJWEXAODU-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.17h， 生成 5-phenyl-4-(piperidin-1-yl)-6H-benzo[b]tetrazolo[1,5-d][1,4]diazepine
  参考文献：
  名称：

  Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation

  摘要：

  A two-step strategy for the synthesis of arrays of tricyclic tetrazolo-fused benzodiazepines and benzodiazepinones has been investigated. The protocol uses ortho-N-Boc phenylisocyanides and phenylglyoxaldehydes or ethyl glyoxylate in the four-component Ugi-azide reaction to afford MCR (MultiComponent Reactions) derived adducts equipped with the desired diversity inputs. A subsequent acidic treatment (TFA/DCE) allows a simultaneous deprotection-cyclization leading to the final products. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.04.068