4-acetyl-N-(2,4,6-trimethylphenyl)benzenesulfonamide | 1071347-77-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-N-(2,4,6-trimethylphenyl)benzenesulfonamide
• CAS: 1071347-77-7
• 化学式: C₁₇H₁₉NO₃S
• 分子量: 317.409
• InChiKey: ZVJSSNDOFVJGBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-乙酰基苯磺酰氯 、 2,4,6-三甲基苯胺 在 吡啶 作用下， 生成 4-acetyl-N-(2,4,6-trimethylphenyl)benzenesulfonamide
  参考文献：
  名称：

  Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

  摘要：

  The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.012

文献信息

• Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
  作者：Steven M. Sparks、Grace Chen、Jon L. Collins、Dana Danger、Steven T. Dock、Channa Jayawickreme、Stephen Jenkinson、Christopher Laudeman、M. Anthony Leesnitzer、Xi Liang、Patrick Maloney、David C. McCoy、David Moncol、Vincent Rash、Thomas Rimele、Padmaja Vulimiri、James M. Way、Sean Ross

  DOI：10.1016/j.bmcl.2014.05.012

  日期：2014.7

  The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein. (C) 2014 Elsevier Ltd. All rights reserved.