3-tert-butyladamantanol | 63263-15-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-tert-butyladamantanol
• 英文别名: 3-Tert-butyladamantan-1-ol
• CAS: 63263-15-0
• 化学式: C₁₄H₂₄O
• 分子量: 208.344
• InChiKey: QNJLHMWTJXQXQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-tert-Butyladamantan 在 lithium aluminium tetrahydride 、 ammonium cerium(IV) nitrate 作用下， 生成 3-tert-butyladamantanol 、 N-<1-(3-tert-butyladamantyl)>acetamide
  参考文献：
  名称：

  硝酸铈铵在乙腈中促进的某些环烷烃的光化学氧化和自氧化

  摘要：

  在室温下，硝酸铈铈铵在乙腈中可光化学促进金刚烷，降冰片烷和环己烷的氧化和自氧化，这两个过程均非常有效且对金刚烷具有选择性。

  DOI：

  10.1016/s0040-4039(00)96015-5

文献信息

• PIPERAZINE-PIPERIDINE COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
  申请人：Long Daniel D.

  公开号：US20130287730A1

  公开（公告）日：2013-10-31

  The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

  这项发明提供了式(I)的化合物： 其中变量在规范中定义，或其药用盐，这些化合物是乙型肝炎病毒复制的抑制剂。该发明还提供了包括这些化合物的药物组合物，使用这些化合物治疗乙型肝炎病毒感染的方法，以及用于制备这些化合物的工艺和中间体。
• Water Repellent Additive for Immersion Resist
  申请人：Central Glass Company, Limited

  公开号：US20130216960A1

  公开（公告）日：2013-08-22

  Disclosed is a water repellent additive for an immersion resist, which is composed of a fluorine-containing polymer that has a repeating unit represented by general formula (1). By adding the water repellent additive to a resist composition, the resist composition can be controlled to have high water repellency during exposure and to exhibit improved solubility in a developing solution during development. [In the formula, R 1 represents a hydrogen atom, a fluorine atom, a methyl group or a trifluoromethyl group; R 2 represents a heat-labile protecting group; R 3 represents a fluorine atom or a fluorine-containing alkyl group; and W represents a divalent linking group.]

  本发明涉及一种浸渍型光阻的疏水添加剂，该添加剂由具有由通式（1）表示的重复单元的含氟聚合物组成。通过将疏水添加剂添加到光阻组合物中，可以控制光阻组合物在曝光期间具有高疏水性，并在显影过程中表现出改善的溶解度。[在公式中，R1表示氢原子，氟原子，甲基或三氟甲基基团; R2表示热敏保护基团; R3表示氟原子或含氟烷基团; W表示二价连接基团。]
• Oxidative Functionalization of Adamantane and Some of Its Derivatives in Solution
  作者：M. Mella、M. Freccero、T. Soldi、E. Fasani、A. Albini

  DOI：10.1021/jo951645y

  日期：1996.1.1

  1,2,4,5-Benzenetetracarbonitrile (TCB) is irradiated in the presence of adamantane (1) and some of its derivatives. The singlet excited state of TCB is a strong oxidant, and there is various evidence, including time-resolved spectroscopy, to prove that SET from the alkane to TCB1* takes place and yields the corresponding radical ions. The adamantane radical cation deprotonates from the bridgehead position, and the resulting radical couples with TCB-.. Deprotonation via the radical cation occurs with a number of substituted adamantanes and remains the exclusive or predominating reaction also with derivatives containing a potential electrofugal group, such as one of the following carbocations: t-Bu, CH(2)OMe, CH2OH (notable here is that C-H deprotonation is more efficient than O-H deprotonation). A carboxy group is lost more efficiently than a proton, however. In contrast, detaching of such cations is the main process when the radical cations of substituted adamantanes is produced anodically. This different behavior is explained on the basis of thermochemical calculation and of the different environments experienced by the radical cation in the two cases, viz reaction from the solvated radical cation in the first case and from the substrate adsorbed on the anode in the latter one. 1-Methoxyadamantane deprotonates from the methyl group, a reaction explained by the different structure of the radical cation. On the other hand, the radical NO3., conveniently produced by photolysis of cerium(IV) ammonium nitrate, reacts by hydrogen abstraction with selective attack at the bridgehead position and little interference by substituents and thus offers a useful way for the selective oxidative functionalization of adamantanes.
• Method for Inhibition of Potential-Dependent Cation Channel
  申请人：Takatoku Hiroko

  公开号：US20130045177A1

  公开（公告）日：2013-02-21

  An excellent potential-dependent cation channel inhibitor or an excellent masking agent is provided. Disclosed is a method for inhibiting a potential-dependent cation channel or a method for masking olfaction, both of which include administering an adamantane derivate represented by the following formula (1) or a salt thereof [wherein R′ and R 2 are identical with or different from each other, and each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and X represents —OH, —R 3 —OH (wherein R 3 represents an alkylene group having 1 to 6 carbon atoms), —NH 2 , —R 4 —NH 2 (wherein R 4 represents an alkylene group having 1 to 6 carbon atoms), —COOH, —R 5 —COOH (wherein R 5 represents an alkylene group having 1 to 6 carbon atoms), —CO-R 6 (wherein R 6 represents an alkyl group having 1 to 6 carbon atoms), —CO—R 7 —COO—R 8 (wherein R 7 represents an alkylene group having 1 to 6 carbon atoms, and R 8 represents an alkyl group having 1 to 6 carbon atoms), or —NHCO—R 9 (wherein R 9 represents an alkyl group having 1 to 6 carbon atoms)].
• Polymerizable Fluorine-Containing Sulfonate, Fluorine-Containing Sulfonate Resin, Resist Composition And Pattern-Forming Method Using Same
  申请人：Takihana Ryozo

  公开号：US20130209937A1

  公开（公告）日：2013-08-15

  According to the present invention, there is provided a sulfonate resin having a repeating unit of the following general formula (3): where X each independently represents a hydrogen atom or a fluorine atom; n represents an integer of 1 to 10; R 1 represents a hydrogen atom, a halogen atom, a C 1 -C 3 alkyl group or a C 1 -C 3 fluorine-containing alkyl group; R 2 represents either R A O or R B R C N; and M + represents a monovalent cation. The sulfonate resin has an onium sulfonate incorporated in a side chain thereof with an anion moiety of the sulfonate salt fixed to the resin and can suitably be used as a resist resin having a high solubility in propylene glycol monomethyl ether acetate.